Projects
Natural and Artifical Genetic Variation in Microbes KU Leuven
One of the main research topics in biology is the identification of the (combination of) mutations that underlie a specific phenotype or physiological adaptation. Many phenotypes and diseases depend on multiple mutations in multiple genes (loci). In many cases, there is a complex interaction between these mutations - a specific mutation may only play a role when other mutations are also present. Complex genetic interactions are present in all ...
Coping with geographic mosaics of stressors: unravelling the interplay of genetic and non-genetic trait variation in natural landscapes KU Leuven
The identification of genetic variation linked to canine cranial cruciate ligament rupture. Ghent University
Cranial cruciate ligament rupture (CCLR) is a highly prevalent multifactorial, polygenetic disorder. The aim of this research project is to identify genetic variation linked to CCLR by whole exome sequencing. The identified causal genetic variation will enable us to reduce the prevalence of this disorder in the dog population.
Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s disease KU Leuven
In recent years, there have been major developments in ’omics technologies. Long read sequencing now produces highly accurate reads from single molecules with theoretically unlimited length. Long reads enable us to assemble whole human genomes de novo, study complex genomic regions and large structural variants, all of which are particularly difficult through conventional short read technologies. It also allows us to directly study DNA ...
Study into the role of genetic variation in NPR3 in the regulation of endochondral bone formation and bone growth. University of Antwerp
Understanding the role of old genomic variation in rapid adaptation. University of Antwerp
Finalizing CNV-WebStore, an integrated platform for analysis, storage and interpretation of clinically relevant structural genomic variation. University of Antwerp
A novel and generic methodology for In-Field Motion tracking and application for the development and validation of models for Crowd-induced loading on footbridges KU Leuven
As materials become stronger and structures lighter, they become more lively under human-induced loading. Hence, vibration serviceability is becoming a key design criterion, rapidly replacing the ultimate limit state when determining the shape and dimensions of footbridges, (public) buildings and grandstands. However, the currently available load models are oversimplified and disregard the ever more important human-structure interaction ...
Spatial and temporal petrological-geochemical variations in the West Aegean arc: influence of local geodynamics parameters on magma genesis Ghent University
Three volcanic islands of the South Aegean arc, representing a 25km across-arc setting, will be studied petrologically and geochemically studied will improve our understanding of the different sources and processes contributing to magma genesis in continental subduction zone settings. This will be achieved through study of thin sections, chemical whole rock analyses (ICP-OES, ICP-Q-MS, MC-ICP-MS) and mineralogical analyses (SEM-EDS and ...