Projects
Understanding embryonic chromosome instability and the origins of structural genetic variation by genome sequencing of single blastomeres. KU Leuven
Although a cell produces an assortment of products that protect, inspect and if necessary heal its valuable genetic code, DNA-mutations can accumulate during a cell’s life cycle. This is exemplified by the acquisition of somatic genetic lesions that cause cancer, but also by the birth of disabled children due to a genomic aberration acquired during gametogenesis or early embryogenesis. In fact, most likely we all are genetic mosaics early on ...
Profiling (sub)clonal architecture and phylogeny in tumors by novel techniques for whole-genome sequence data mining and single-cell genome sequencing. KU Leuven
Integration of long read genome sequencing and single-cell multi-omics to identify genetic variation underlying Parkinson’s disease KU Leuven
In recent years, there have been major developments in ’omics technologies. Long read sequencing now produces highly accurate reads from single molecules with theoretically unlimited length. Long reads enable us to assemble whole human genomes de novo, study complex genomic regions and large structural variants, all of which are particularly difficult through conventional short read technologies. It also allows us to directly study DNA ...
GENOmics in MEDicine: From whole genome sequencing towards personalized medicine (GENOMED). University of Antwerp
Whole Genome Sequencing to streamline TB diagnosis, improve TB surveillance and optimize individualized TB treatment: a pragmatic trial. University of Antwerp
Development of a Centre for Whole Genome Sequencing studies of Mycobacterium. University of Antwerp
Identification of cancer driver mutations in the non-coding genome by integrative genomics and regulome sequencing. KU Leuven
Improved infectious diseases control in Peru through sustainable capacity building for bioinformatics and genome sequencing. University of Antwerp
Prenatal genome sequencing to map embryonic lethal and developmental disorder genes KU Leuven
Population screening pregnant women by ultrasound led to the identification of a congenital malformation (birth defect) in up to 2-5%. Presence of a birth defect may be responsible for 20% of perinatal deaths. Genetic investigations are an important approach to identify genes involved in developmental programs and are clinically important in the evaluation and clinical triage of fetal structural anomalies. The absence of a confirmed genetic ...