Strategies for boosting local adenosine A1 signaling as a treatment for focal epilepsy: from positive allosteric modulators of the inhibitory A1 receptor to deep brain stimulation and photopharmacology. Ghent University
Epilepsy is a common neurological disorder, characterized by spontaneous recurrent epileptic seizures. Despite adequate treatment with anti-epileptic drugs, still 30% of the patients continue to have seizures or suffer from severe medication-related side effects due to the large doses of AED they need to take. Therefore, innovative treatments for epilepsy are highly needed. The neuromodulator adenosine, which interacts with A1 receptors ...