Influence of formulation and process parameters on the formation of coated solid dispersion nano- and microparticles by single step coaxial electrospraying KU Leuven
The number of new drugs with low aqueous solubility and hence low therapeutic efficiency is very high. One formulation strategy to increase the solubility and the uptake in the body is the use of amorphous solid dispersions (this is a solid product that is made up of a non-crystalline polymer in which the drug is chaotically distributed but that releases the drug upon contact with water). Often such an instantaneous release needs to be ...