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NEURON II - Proteolytic remodeling of the extracellular matrix in aberrant synaptic plasticity underlying epilepsy evoked by traumatic brain injury (TBI Epilepsy). University of Antwerp

Stefanie Dedeurwaerdere
Translational Neurosciences (TNW)
In the present project we aim at testing a hypothesis that MMP-9 and uPA/uPAR contribute to circuitry remodeling during post-traumatic epileptogenesis. We focus on those two molecular systems, because there is a strong support for their involvement in other models of epileptogenesis, as well as the partners of this consortium have excellent tools and expertise to investigate these molecules.

Prospective longitudinal MRI and PET studies of epileptogenesis and brain plasticity in epilepsy using [18F]fluorodeoxyglucose (FDG), [18F]flumazenil (FMZ), [18F]MK-9470 in small animals with epilepsy. KU Leuven

Wim Van Paesschen
Laboratory for Epilepsy Research, Biomedical MRI
The aim of the project is to investigate epileptogenesis and brain plasticity due to seizures using two complementary animal models that closely represent temporal lobe epilepsy in humans, i.e. the amygdala kindling model and the status epilepticus model. We intend to characterize several neurobiological processes during epileptogenesis and chronic epilepsy in these two animal models using video-EEG monitoring, and in vivo structural (MRI and ...

Nodding Syndrome: a trans-disciplinary approach to identify the cause and decrease the incidence of river epilepsy (NSETHIO). University of Antwerp

Robert Colebunders
Global Health Institute (GHI), Epidemiology and social medicine (ESOC)
Nodding syndrome (NS) is a neurological, incurable syndrome, currently affecting mainly children between 5 and 15 years of age in South Sudan, Uganda and Tanzania. Since 1950, when NS was first described, its cause has remained a mystery. NS is characterized by head-nodding (an atonic form of epilepsy), often followed by clonic - tonic seizures, developmental retardation and faltering growth. In the affected regions, NS is a major public health ...

Prevalence of epilepsy and sleep-wake disturbances in Alzheimer's disease KU Leuven

Wim Van Paesschen
Laboratory for Epilepsy Research, Laboratory of Respiratory Diseases and Thoracic Surgery (BREATHE), Dynamical Systems, Signal Processing and Data Analytics (STADIUS), Neuropsychiatry

Alzheimer’s disease (AD) is the most common neurodegenerative disease causing dementia and one of the leading causes of death. Currently, there is no curative therapy for AD. Epilepsy and sleep-wake disturbances are common co-morbid conditions in AD which are often present in an early stage of the disease. They not only cause more rapid deterioration of the disease by impairing memory and behaviour, but are also an increasing burden on the ...

Learning from Structured EEG and fMRI Data Supporting the Diagnosis of Epilepsy KU Leuven

Sabine Van Huffel
ESAT - STADIUS, Stadius Centre for Dynamical Systems, Signal Processing and Data Analytics, Laboratory for Epilepsy Research
Epilepsy is a neurological condition that manifests in epileptic seizures as a result of an abnormal, synchronous activity of a large group of neurons. Depending on the affected brain regions, seizures produce various severe clinical symptoms. Epilepsy cannot be cured and in many cases is not controlled by medication either. Surgical resection of the regionresponsible for generating the epileptic seizures might offer remedy for these patients. ...

Multimodal profiling of people with epilepsy to determine which signals are clinically useful for long-term home monitoring KU Leuven

Wim Van Paesschen
Laboratory for Epilepsy Research, Dynamical Systems, Signal Processing and Data Analytics (STADIUS), Locomotor and Neurological Disorders

Epilepsy is a serious and common neurological disorder marked by recurrent epileptic seizures, caused by abnormal, excessive and synchronous electrical discharges in the brain. It has a prevalence of around 0.5% and affects nearly 50 million people worldwide. As many as 30% of patients with epilepsy are refractory, which means that epilepsy is not controlled with two or more well used anti-epileptic drugs. In order to develop and evaluate new ...

Studying brain network changes in epilepsy by combining functional magnetic resonance imaging, intracranial electroencephalography and opto-/chemogenetics to unravel biomarkers for disease prognosis and efficacy of anti-epileptic treatments Ghent University

Christian Vanhove
Department of Electronics and information systems

Epilepsy is a neurological disorder characterized by recurrent epileptic seizures. In about 30% to
40% of the patients with epilepsy, the seizures are not sufficiently controlled with anti-epileptic
drugs (AEDs). Currently, it is still very difficult to predict which patients will respond to AEDs or
deep brain stimulation (DBS), another treatment possibility. Research has shown that abnormal
functional brain networks ...

New approaches for detection and modulation of abnormal brain networks in a preclinical model for epilepsy based on a combination of functional magnetic resonance imaging, optogenetics, chemogenetics and intracranial electroencephalography Ghent University

Department of Head and Skin, Department of Internal medicine, Department of Electronics and information systems

Epilepsy is a common neurological disorder that is characterized by the occurrence of spontaneous
seizures. Unfortunately, about one third of the patients still have seizures despite treatment with
anti-epileptic drugs (AED). In addition, many patients have severe side effects due the large doses
of AED they need to take. Other treatments are required to improve the quality of life of those
patients. In order to find ...