Investigating current gaps in time-dependent inhibition (TDI) and induction drug-drug interactions (DDIs). A focus on CYP3A4 and non-CYPs drug metabolizing enzymes (DMEs). KU Leuven
The reliable prediction of drug-drug interactions (DDIs) early during drug discovery and development is crucial for an efficient and successful drug development process in the pharmaceutical industry. However, remarkable knowledge gaps exist for specific DDI mechanisms, including: (i) time-dependent ('suicide') inhibition (TDI) of drug metabolising enzymes, and (ii) drug-mediated induction of drug metabolising enzymes. This project will ...