Projects
Use of fluorescent probes to study pharmacokinetics in zebrafish (Danio rerio) embryos and larvae KU Leuven
Despite the number of tools available for detecting toxicity in the drug discovery pipeline, post-marketing withdrawal due to toxic effects continues to be of an issue in the pharmaceutical industry. Many efforts have been made over the last years to improve the predictivity of in vitro and in vivo models that preclinically determine safety profiles of chemicals. Zebrafish (Danio rerio) offer new opportunities in this regard ...
Unraveling the susceptibility and pathogenesis of viral infections using zebrafish KU Leuven
Aquatic systems under multiple stress: a new paradigm for integration aquaculture and ecotoxicology research. University of Antwerp
BioMedAqu: Aquaculture meets Biomedicine: Innovation in Skeletal Health research Ghent University
Skeletal anomalies in farmed fish are a continuous problem for global aquaculture, affecting fish welfare, performance, and product quality. Aquaculture research has made considerable progress in reducing the incidence of deformities, but new species, intensified production, the damned for sterile fish, delicate early life stages and new fish feed ingredients are a continuous challenge. The use of zebrafish (Danio rerio) and medaka (Oryzias ...
Sabbactical Ann Huysseune A new paradigm for pharyngeal tooth formation? Ghent University
Hypotheses on the evolutionary origin of the vertebrate dentition have largely revolved around the developmental basis of pharyngeal
teeth (whether endoderm- or ectoderm-derived). As a corollary to our U+2018modified outside inU+2019 hypothesis (Huysseune et al., 2009), I propose
that the development of allegedly endoderm-derived pharyngeal teeth in teleost fish requires a contribution, or signalling, from the
ectoderm. Using ...
Aquaculture meets Biomedicine: Innovation in Skeletal Health research Ghent University
Skeletal anomalies in farmed fish are a continuous problem for global aquaculture, affecting fish welfare, performance, and product quality. Aquaculture research has made considerable progress in reducing the incidence of deformities, but new species, intensified production, the damned for sterile fish, delicate early life stages and new fish feed ingredients are a continuous challenge. The use of zebrafish (Danio rerio) and medaka (Oryzias ...
Dendritic mitochondrial energy channeling as driver of successful axonal regeneration? KU Leuven
Treating ischemic and traumatic central nervous system (CNS) insults as well as neurodegenerative disorders like Alzheimer's and Parkinson's disease, multiple sclerosis and glaucoma, is one of the leading medical and socioeconomic challenges faced by our aging society. These currently incurable conditions lead to progressive neuronal degeneration and irreversible impairments in the adult mammalian CNS, as damaged neurons cannot be repaired, ...