Projects
Uncovering mechanisms of TLX1/TLX3 oncogenic cooperation in leukemia KU Leuven
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive haematological disease which arises from the malignant transformation of developing T-cell progenitors into leukemia cells. T-ALL is classified into at least five distinct molecular subtypes based on the ectopic expression of transcription factors, such as TLX1 and TLX3, which is caused by chromosomal rearrangements.
The main consequence of these ectopic transcription factors ...
Cooperation and competition in European defence policy University of Antwerp
Research stay at VU Amsterdam on inter-municipal cooperation in the Netherlands Hasselt University
Competition and cooperation in European defence: private versus public governance and EU policy outcomes. University of Antwerp
Regulatory Cooperation Between International Organizations: Uncovering Innovative International Law-Making Processes KU Leuven
International organizations have conquered an important place in international law in the past decades. With hundreds of international organizations in existence today and many working in the same fields and addressing similar issues, there is a growing need for coordinated actions and unified responses to better tackle globalchallenges. As a result, international organizations often cooperate in their regulatory activities to address gaps, ...
Trade at the Crossroads of the Pacific and Indian Ocean Worlds: Credit Networks and the Financial Structure of Merchant Cooperation in Eighteenth-Century Manila KU Leuven
During the course of the Manila galleon era (1571–1815), merchant networks were essential to the operation of trans-Pacific and Indian Ocean routes, though until now we have had little systematic evidence of how these operated. The allocation of networkable resources, specifically credit, can be gleaned from Spanish archival record and acts as a proxy for a less tangible resource: mercantile trust. The National Archives of the Philippines ...
The role of NKX2-1 in T-cell acute lymphoblastic leukemia and NKX2-1 cooperation with the ribosomal RPL10 R98S and NOTCH1 mutations. KU Leuven
T-cell acute lymphoblastic leukemia (T-ALL) is caused by accumulation of at least 10 mutations in immature T-cells. This accumulation does not happen randomly: particular mutations often co-occur while others are never found together. Recent work revealed interesting biology showing how co-occurring mutations actively cooperate in driving leukemia. Ectopic expression of the transcription factor NKX2-1 frequently co-occurs with the ribosomal ...
Oncogenic cooperation between TAL1 expression and AKT pathway activation in T-cell acute lymphoblastic leukemia KU Leuven
TAL1 is an oncogene that is ectopically expressed in about one third of T-ALL patients and these cases often also harbor additional mutations that lead to activation of the PI3K/AKT signaling pathway. TAL1 acts as a transcription factor that regulates the expression of many other genes, but it remains unknown how TAL1 cooperates with PI3K/AKT pathway activation and how this cooperation supports leukemia development. In this project we aim to ...
Cooperation of TLX3 with epigenetic changes in the development of T-cell acute lymphoblastic leukemia KU Leuven
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological cancer, which arises from the malignant transformation of developing T-cell progenitors. Genetic studies have identified a variety of chromosomal defects and point mutations that drive T-ALL development. TLX3 is a transcription factor that is frequently overexpressed in T-ALL. Interestingly, TLX3 expressing T-ALL cases often show inactivation of epigenetic factors such ...