Projects
Development and validation of active and passive immunotherapy targeted at protein Tau in transgenic mouse models for Alzheimer's disease KU Leuven
Inter-relations of protein Tau, GSK3 and Nectin-3 in synaptic structure and plasticity in the hippocampus of mouse models for Alzheimer's disease KU Leuven
Do schools and teachers leave their mark? Studies on long-term effects of schools and teachers on student outcomes KU Leuven
In the field of educational effectiveness research, teacher and school effects are most often studied in the short term. Long-term school and teacher effects are less often studied and the findings are inconsistent. The objective of this dissertation is to study long-term school and teacher effects. The main question is: do schools or teachers still influence students’ outcomes at the moment these students already changed school or teacher? ...
Discovery of Antiseizure Compounds in Zebrafish Models for the Treatment of Drug-Resistant Epilepsy KU Leuven
With 70 million people affected worldwide is epilepsy one of the most common neurological diseases characterized by unpredictable, unprovoked, recurrent seizures. Moreover, the disease is often accompanied by psychiatric and cognitive comorbidities, affecting dramatically the quality of life of patients. So far, pharmacological intervention is the first-line treatment for epilepsy. Unfortunately, about 30% of patients experience seizures that ...
Local and systemic immune interactions in malignant gliomas KU Leuven
Glioblastoma (GBM), the most frequent primary intrinsic brain tumor, is without any doubt one of the most devastating diseases known to mankind. GBM are currently being treated with neurosurgical resection followed by radio- and chemotherapy. However, despite this treatment, prognosis for these patients is grim with a median survival of only 15 months and less than 20% 3-year survival rates. Already at diagnosis, GBM cells are infiltrating ...
BIOMECHANICAL CHARACTERIZATION OF BICYCLE ACCIDENTS RELATED HEAD INJURIES KU Leuven
Electrical interaction with the abnormal brain cavity wall to reduce cavity-related symptoms: proof-of-concept study in the rat KU Leuven
On each neurosurgery and neuroanatomy ward around the world lie patients with an abnormal brain cavity (aBC). Such an aBC develops because neurons are lost as a result of brain damage due to e.g. a stroke or traumatic brain injury. Symptoms associated with an aBC range from motor impairment such as paresis to psychiatric symptoms such as depression. Despite a wide range of available therapies, these symptoms often remain, even years ...
The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models. KU Leuven
End-to-end Training of Deep Neural Networks for Monocular Autonomous Navigation - A Feasibility Study KU Leuven
This PhD investigates the feasibility of applying Deep Learning methods to monocular autonomous navigation. Deep Learning has shown impressive results over the last seven years in computer vision, moving from hand crafted algorithms to end-to-end learned models. Whether the same idea of moving from hand crafted algorithms to end-to-end trained deep neural networks is also applicable to monocular navigation is still an open ...