An information theoretic approach for the evaluation of correlates of protection in a vaccine setting. Hasselt University
Evaluating the protective efficacy of a vaccine without having to measure clinical endpoints has significant advantages and immunological endpoints, also called surrogates of protection (SoP), are often used for vaccine development, licensure and effectiveness monitoring. SoP have played an important role in the development of many of the current childhood combination vaccines. However, SoP need to be evaluated before they can be reliably used ...