Targeting the acid pocket: evaluation of a candidate cornerstone of GERD treatment KU Leuven
Achalasia is an uncommon chronic motility disorder of the esophagus with an annual incidence of 1 per 100.000 persons, characterized by absence of peristalsis and defective relaxation of the lower esophageal sphincter (LES). Resulting in impaired bolus propulsion and stasis of food, with dysphagia and regurgitation as main symptoms. The cause of achalasia remains unknown, therefore treatment is confined to dilation or myotomy of the LES. ...