Publications
Interferons and other cytokines, genetics and beyond in COVID-19 and autoimmunity KU Leuven
Humoral and cellular immune correlates of protection against COVID-19 in kidney transplant recipients Institute of Tropical Medicine University of Antwerp
As solid organ transplant recipients are at high risk of severe COVID-19 and respond poorly to primary SARS-CoV-2 mRNA vaccination, they have been prioritized for booster vaccination. However, an immunological correlate of protection has not been identified in this vulnerable population. We conducted a prospective monocentric cohort study of 65 kidney transplant recipients who received 3 doses of BNT162b2 mRNA vaccine. Associations among ...
Evaluation of a surrogate virus neutralization test for high-throughput serosurveillance of SARS-CoV-2 Institute of Tropical Medicine University of Antwerp
High-throughput serological tests that can detect neutralizing antibodies against SARS-CoV-2 are desirable for serosurveillance and vaccine efficacy evaluation. Although the conventional neutralization test (cVNT) remains the gold standard to confirm the presence of neutralizing antibodies in sera, the test is too labour-intensive for massive screening programs and less reproducible as live virus and cell culture is involved. Here, we ...
Development of Nanobodies Against Hemorrhagic and Myotoxic Components of Bothrops atrox Snake Venom Vrije Universiteit Brussel
Snake envenoming is a globally neglected public health problem. Antivenoms produced using animal hyperimmune plasma remain the standard therapy for snakebites. Although effective against systemic effects, conventional antivenoms have limited efficacy against local tissue damage. In addition, potential hypersensitivity reactions, high costs for animal maintenance, and difficulties in obtaining batch-to-batch homogeneity are some of the factors ...
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages KU Leuven
Predictors of neutralizing antibody response to BNT162b2 vaccination in allogeneic hematopoietic stem cell transplant recipients University of Antwerp KU Leuven Institute of Tropical Medicine
Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom. Vrije Universiteit Brussel
Structural Basis for the Specific Neutralization of Stx2a with a Camelid Single Domain Antibody Fragment Vrije Universiteit Brussel University of Antwerp
Background: Shiga toxin-producing Escherichia coli (STEC) are a subset of pathogens leading to illnesses such as diarrhea, hemolytic uremic syndrome and even death. The Shiga toxins are the main virulence factors and divided in two groups: Stx1 and Stx2, of which the latter is more frequently associated with severe pathologies in humans. Results: An immune library of nanobodies (Nbs) was constructed after immunizing an alpaca with recombinant ...
The Molecular Mechanism of Shiga Toxin Stx2e Neutralization by a Single-domain Antibody Targeting the Cell Receptor-binding Domain Vrije Universiteit Brussel
disease in newly weaned pigs. This severe disease is characterized
by neurological disorders, hemorrhagic lesions, and frequent
fatal outcomes. Stx2e consists of an enzymatically active
A subunit and five B subunits that bind to a specific glycolipid
receptor on host cells. It is evident that antibodies binding to the
A subunit or the B subunits of ...