Researcher
Serge Muyldermans
- Research Expertise:
- Fundamental Research in Eukaryotic Gene Expression. Protein-DNA interaction. Protein Structure and Action. (X-ray crystallography) Antibody Engineering. Protein engineering. (Site directed mutagenesis/Enzym kinetics).
- Cloning and production of recombinant antibody fragments derived from camelidae
- Keywords:Applied biological sciences, biotechnology, General and logistic services
- Disciplines:Applied immunology, Medical molecular engineering of nucleic acids and proteins, Medical biotechnology diagnostics, Other veterinary sciences not elsewhere classified
- Users of research expertise:
- Fundamental Research in Eukaryotic Gene Expression. Protein-DNA interaction. Protein Structure and Action. (X-ray crystallography) Antibody Engineering. Protein engineering. (Site directed mutagenesis/Enzym kinetics).
- Cloning and production of recombinant antibody fragments derived from camelidae
Affiliations
- Vriendenkring VUB (Office)
Member
From1 Oct 2019 → Today - Vriendenkring VUB (Office)
Member
From1 Oct 2019 → 20 Oct 2022 - Department of Bio-engineering Sciences (Department)
Member
From8 Apr 2019 → 30 Sep 2021 - FORMER_Cellular and Molecular Immunology (Research group)
Member
From1 Feb 2003 → 1 Oct 2019 - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 2001 → 23 Jul 2015 - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 1998 → 30 Sep 2019 - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 1998 → 30 Sep 2003 - Department of Bio-engineering Sciences (Department)
Member
From1 Feb 1997 → 30 Sep 1998 - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 1980 → 30 Sep 2003 - Ultrastructure (Research group)
Member
From30 Sep 1977 → 31 Dec 2002
Projects
1 - 10 of 15
- IOF POC Project SYNALI : Development and application of a Synthetic Nanobody LibraryFrom1 Jan 2022 → TodayFunding: IOF - technology concept exploration
- SRP-Onderzoekszwaartepunt: Exploiting Peptides: Protein Binders, Modulators and Inhibitors for Imaging and Therapy [Exploit-PeptIT]From1 Mar 2019 → TodayFunding: BOF - projects
- Nanobody-based inhibitors of connexin hemichannels and pannexin channels as novel therapeutics for the treatment of inflammatory hepatic and cardiovascular diseases.From1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- ERA-NET NEURON cofund JTC 2016: 'Spinal cord repair by endogenous stem cells from the spinal niche'From1 Jul 2017 → 30 Jun 2019Funding: FWO research project (including WEAVE projects)
- Internationaal Congres: Center for Translational Research Annual Conference 2015: Novel Approaches in Biomedical research. (01/7/2015-4/07/2015)From1 Jul 2015 → 31 Dec 2015Funding: VLIR-UOS International Conferences (INCO)
- Targeted nanoparticles for combined multimodal imaging and therapy: NanoCoMITFrom1 Jan 2015 → 31 Dec 2018Funding: SBO (Strategic basic research)
- Site-specific functionalization of Nanobodies as probes for Molecular Imaging and Therapy - Theranostic toolFrom1 Jan 2015 → 31 Dec 2018Funding: FWO research project (including WEAVE projects)
- Development of Therapeutic Nanobodies Targeting Human Acute Myeloid Leukemia Stem Cells.From1 Oct 2013 → 30 Sep 2017Funding: FWO fellowships
- Nanobody-based Proximity Ligation Assay for Human ToxocariasisFrom1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- SRP (Zwaartepunt): Targeting of inflammation linked to infectious diseases and cancerFrom1 Nov 2012 → 31 Oct 2017Funding: BOF - Concerted Research Project from 1994
Publications
1 - 10 of 175
- Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury(2023)
Authors: Raf Van Campenhout, Timo W M De Groof, Prashant Kadam, Brenda R. Kwak, Serge Muyldermans, Nick Devoogdt, Mathieu Vinken
Pages: 371 - Epitope mapping of nanobodies binding the Alzheimer's disease receptor SORLA(2023)
Authors: Giulia Monti, Cécile Vincke, Melanie Lunding, Anne Mette G Jensen, Peder Madsen, Serge Muyldermans, Mads Kjolby, Olav M Andersen
Pages: 17-27 - Nanobodies for the Early Detection of Ovarian Cancer(2022)
Authors: Lan-Huong Tran, Geert-Jan Graulus, Cécile Vincke, Natalia Smiejkowska, Anne Kindt, Nick Devoogdt, Serge Muyldermans, Wanda Guedens
- Sensitive Protein Detection Using Site-Specifically Oligonucleotide-Conjugated Nanobodies(2022)
Authors: Rasel A Al-Amin, Phathutshedzo M Muthelo, Eldar Abdurakhmanov, Cécile Vincke, Shahnaz P Amin, Serge Muyldermans, U Helena Danielson, Ulf Landegren
Pages: 10054-10061 - Neutralizing Dromedary-Derived Nanobodies Against BotI-Like Toxin From the Most Hazardous Scorpion Venom in the Middle East and North Africa Region(2022)
Authors: Rahma Ben Abderrazek, Ayoub Ksouri, Faten Idoudi, Sayda Dhaouadi, Emna Hamdi, Cécile Vincke, Azer Farah, Zakaria Benlasfar, Hafedh Majdoub, Mohamed El Ayeb, et al.
- AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer's disease model(2022)
Authors: Marika Marino, Lujia Zhou, Melvin Y Rincon, Zsuzsanna Callaerts-Vegh, Jens Verhaert, Jérôme Wahis, Eline Creemers, Lidia Yshii, Keimpe D Wierda, Takashi Saito, et al.
- Nanobodies as binding-chaperones stabilize the recombinant Bombyx mori acetylcholinesterase and protect the enzyme activity in pesticide detection(2022)
Authors: Jun Cai, Ema Romao, Jiadong Li, Liping Li, Zhifeng Wang, Yuwei Li, Jinyi Yang, Yudong Shen, Zhenlin Xu, Serge Muyldermans, et al.
- Nanobodies(2022)
Authors: Fangling Ji, Jun Ren, Cécile Vincke, Lingyun Jia, Serge Muyldermans
Pages: 3-17 - Development of Nanobodies against Mal de Río Cuarto virus major viroplasm protein P9-1 for diagnostic sandwich ELISA and immunodetection(2021)
Authors: Gabriela Llauger, Demián Monti, Matías Adúriz, Ema Romao, Analía Delina Dumón, María Fernanda Mattio, Andrés Wigdorovitz, Serge Muyldermans, Cécile Vincke, Viviana Parreño, et al.
- Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha(2021)
Authors: Karen De Vlaminck, Ema Romao, Janik Puttemans, Ana Rita Pombo Antunes, Daliya Kancheva, Isabelle Scheyltjens, Jo A Van Ginderachter, Serge Muyldermans, Nick Devoogdt, Kiavash Movahedi, et al.
Patents
1 - 10 of 10
- Treatment of fungal infections or diseases (Inventor)
- Virus-like particles and uses thereof (Inventor)
- Treatment of fungal infections or diseases (Inventor)
- Virus-like particles and uses thereof (Inventor)
- Single domain antibodies capable of modulating BACE activity (Inventor)
- Single domain antibodies capable of modulating BACE activity (Inventor)
- Virus-like particles and uses thereof (Inventor)
- Anti-VCAM-1 nanobodies (Inventor)
- Anti-vcam-1 nanobodies (Inventor)
- Anti-influenza antibody (Inventor)