Projects
Molecular epidemiological approaches in a translational study of complex Alzheimer dementia. University of Antwerp
Molecular correlation between Alzheimer disease and Fragile X syndrome. KU Leuven
Molecular genetic analysis of Alzheimer dementia. University of Antwerp
An integrated approach of genetic epidemiology and molecular genetics in the study of Alzheimer dementia and related phenotypes. University of Antwerp
Defining the interdependence of the brain's vascular dysfunction and the prescence of cerebral amyloid deposits by using new tools in Alzheimer research. University of Antwerp
The physiological and pathological contribution of GSK3 isozymes in normal mice and transgenic Alzheimer mice models. KU Leuven
Effect of spread of tau on functional connectivity patterns in the preclinical and prodromal stage of Alzheimer disease KU Leuven
Dementia is a worldwide growing problem. It is estimated that there will be around 130 million cases of Alzheimer’s disease (AD) by 2050, mainly due to ageing of the baby boom generation. Cognition results from an optimal cooperation of local information processing and interregional integration. This communication can be approximated by the measurement of the functional connectivity, quantified with graph analysis. Neurofibrillary tangles ...
Exploring the role of Aβ, Tau and Tau modulators in inducing neuronal death in a novel humanized mouse model for Alzheimer Disease KU Leuven
Neuronal cell loss is an ultimate hallmark of the many neurodegenerative diseases including Alzheimer’s disease (AD). However, neuronal cell death phenotype is seldom investigated. In AD, the relationship between Amyloid β (Aβ) peptide, Tau, and neuronal death is a central problem. Nevertheless, cell culture or animal models do not reproduce well the cell death phenotype that is crucial to analyze this relation. As it remains unclear to what ...