Border control: getting a grip on nuclear envelope rupture and repair. University of Antwerp
The nuclear lamina is a critical regulator of nuclear structure and function. Defects in its major protein constituents, the A-type lamins, cause a spectrum of diseases referred to as laminopathies. We have discovered that laminopathy patient cells repetitively experience transient ruptures of the nuclear envelope, leading to illegitimate exchange of proteins between the cytoplasm and the nucleus. This feature contributes significantly to ...