mTOR inhibition as a promising strategy to regress atherosclerotic plaques in mice. University of Antwerp
This project aims to study the following topics:1) Role of autophagy in plaque formation and critical regression by everolimus using autophagydeficient mice2) Cholesterol efflux in macrophage-derived foam cells or atherosclerotic mice after everolimus administration3) Effect of everolimus on intraplaque neovascularization and rupture in a unique mouse model showing substantial sprouting of neovessels in the plaque as well as acute plaque ...