Optical frequency combs have become a cornerstone of frequency metrology and are now available as commercial systems based on pulsed fiber lasers. Since the Nobel prize in physics was awarded to John L. Hall and Theodor W. Hänsch in 2006, the application
N-containing heterocycles can be found in several bioactive small molecules, and it is well known that these are very prominent scaffolds in drug discovery. Additionally, the availability of organic reactions for different functionalizations is the key factor that may be limiting the development of new drugs. It is widely accepted that investments in basic chemistry for the development of new synthetic methodologies towards heterocycles are ...
Drug discovery is a lengthy, expensive, difficult, and inefficient process with quite a low rate of new therapeutic discoveries from existing molecules or new molecular entities. These projects generally start with a high-throughput screening campaign of commercially available compound libraries
against the target of interest. However in recent years, it became clear that current combinatorial libraries are not enough. As a mission of ...
The total number of different proteins present in Earth organisms is estimated to be up to 10 million. While their identification in terms of primary sequences is expanding at an increasing rate, elucidation of their function and three-dimensional structure is drastically lacking behind. Most of the currently used approaches in proteomics for unraveling the structure and function of proteins require protein hydrolysis into more manageable ...
Transition metal catalysis lies at the heart of modern innovative science. To expand this area in organic synthesis, the challenge is to identify novel strategies for the formation of organo-metallic intermediates under mild conditions, and to discover new methods for their subsequent transformation. In this proposal we will focus on the trapping of transient C(sp3)- and C(sp2)-Pd species via C-H activation, or employing oxygen/nitrogen ...
The main ambition of the cluster science research field is to understand how matter is built up from an atom over clusters and nanoparticles to larger systems including bulk. Central knowledge in the field is that properties of clusters are strongly size dependent and that zero dimensional quantum confinement determines their physical and chemical properties in a non-scalable way. So far, very little experimental and theoretical information ...
The aim of this project is to perform a pioneering experimental investigation of electronic transport in nano-devices containing multiple superconductor (S)/ graphene (G) interfaces. This, in order to gain fundamental understanding of, and control over, the different competing microscopic transport processes through the present interfaces.
The central focus will be on microscopic transport processes in these multi-terminal devices that ...
Quantum size effects dominate the electric and magnetic properties of few-atom clusters, resulting in strong size dependences and new phenomena, different from bulk behaviour. To exploit the full potential of these atomic size building blocks in functional nanostructured materials one needs to establish a connection between the clusters and the macroscopic world. We propose an innovative approach to interact with the clusters without ...
The density of matter in a nucleus is extremely high: about 10000 billions more dense than gold, which in turn is 20 times more dense than water. In nature, only collapsed stars and black holes have a higher density. Nevertheless, it is possible to further compress nuclear matter: nuclei can be squeezed and elongated like a spring, of course in three dimensions. Oscillations that are created in this way are called compression modes of the ...
I will exploit a novel CMOS microelectrode array chip (MEA) to monitor and genetically modify cells at the single-cell level. First, I will use impedance measurements and cell imaging to identify cell types with distinct functional properties (e.g. proliferation rate, impedance signatures) from heterogeneous glioblastoma models. Second, I will locally electroporate cells to fluorescently tag them and genetically edit their genome, while ...