Harnessing single-cell and spatial transcriptomics to uncover novel insights into the pathological events that trigger the progression of acute-on-chronic liver failure KU Leuven
ACLF is a clinically important syndrome that develops in patients with decompensated cirrhosis. This distinct disease entity is characterized by a rapid deterioration of liver function, the development of organ failure and an extremely high short-term mortality. Currently, no therapy exists and ACLF is managed by organ support and treatment of the precipitating event. Important to note is that patients with ACLF exhibit an immunological ...