Researcher
Steven Goossens
- Keywords:In vitro models, cell biology, in vivo animal models, mouse model, translational research, leukemia, Metastasis
- Disciplines:Hematology, Cancer biology, Cancer therapy
Affiliations
- Department of Diagnostic Sciences (Department)
Member
From1 Oct 2019 → Today - Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → 30 Sep 2019 - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2016 → 30 Sep 2018 - Department of Biomedical molecular biology (Department)
Member
From1 Feb 2000 → 30 Sep 2019
Infrastructure
1 - 1 of 1
- Patient Derived Xenograft Platform Ghent (Consortium coordinator)
Projects
1 - 10 of 22
- Facility : Patiënt-afgeleide xenograft modellen – UGent;From1 Feb 2024 → TodayFunding: BOF - research organisations
- Establishing safety and efficacy of an improved Asparaginase in dog models: final preparation for Phase I clinical trialFrom1 Jan 2024 → TodayFunding: Nonprofit institution or equivalents
- Towards clinical testing of novel stabilized less toxic asparaginases for the treatment of acute lymphoblastic leukemiaFrom20 Dec 2023 → TodayFunding: IOF - technology validation in lab
- Targeting the amino acid stress response (AAR) pathway to treat triple negative breast cancersFrom1 Oct 2023 → TodayFunding: Nonprofit institution or equivalents
- Towards clinical testing of improved, less toxic and less immunogenic, L-asparaginase preparations for the treatment of acute lymphoblastic leukemiaFrom1 Oct 2023 → TodayFunding: BOF - postdoctoral mandates
- Oncogenic Role of SOX11 in T-cell acute lymphoblastic leukemiaFrom1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- Preclinical validation of a less toxic variant for paediatric leukemiaFrom1 Oct 2022 → 30 Sep 2023Funding: Nonprofit institution or equivalents
- A patient derived xenograft (PDX) platform for in vivo evaluation of novel anticancer therapiesFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Replication fork protector dependency factors: novel targets for combination treatment and immunomodulation in neuroblastoma (REINFORCE)From1 Jan 2022 → TodayFunding: BOF - projects
- Targeting MEF2C in immature acute leukemiasFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
Publications
11 - 17 of 17
- Targeting steroid resistance in T-cell acute lymphoblastic leukemia(2019)
Authors: Renate De Smedt, Julie Morscio, Steven Goossens, Pieter Van Vlierberghe
- ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition(2018)
Authors: Nicolas Skrypek, Kenneth Bruneel, Cindy Vandewalle, Eva De Smedt, Bieke Soen, Nele Loret, Joachim Taminau, Steven Goossens, Niels Vandamme, Geert Berx
- Pre-clinical evaluation of second generation PIM inhibitors for the treatment of T-cell acute lymphoblastic leukemia and lymphoma(2018)
Authors: Renate De Smedt, Sofie Peirs, Julie Morscio, Filip Matthijssens, Juliette Roels, Lindy Reunes, Béatrice Lintermans, Steven Goossens, Tim Lammens, Nadine Van Roy, et al.
Pages: e17 - e20 - ZEB proteins in leukemia : friends, foes, or friendly foes?(2018)
Authors: Bieke Soen, Niels Vandamme, Geert Berx, Jürg Schwaller, Pieter Van Vlierberghe, Steven Goossens
- Structure-function studies in mouse embryonic stem cells using recombinase-mediated cassette exchange(2017)
Authors: Tim Pieters, Lieven Haenebalcke, Kenneth Bruneel, Niels Vandamme, Tino Hochepied, Jolanda van Hengel, Dagmar Wirth, Geert Berx, Jody J Haigh, Frans Van Roy, et al.
- Alpha-catenins control cardiomyocyte proliferation by regulating Yap activity
Authors: Jifen Li, Erhe Gao, Alexia Vite, Roslyn Yi, Ludovic Gomez, Steven Goossens, Frans Van Roy, Glenn L Radice
Pages: 70 - 79 - Loss of U+03B1T-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia
Authors: Jifen Li, Steven Goossens, Erhe Gao, Lan Cheng, Koen Tyberghein, Xiying Shang, Riet De Rycke, Frans Van Roy, Glenn L Radice
Pages: 1058 - 1067