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Researcher
Philip Van Damme
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurological and neuromuscular diseases
- See also: Philip Van Damme (Flanders Institute for Biotechnology)
Affiliations
- Van Den Bosch Lab (Research group)
Member
From1 Jan 2017 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today - Research Group Experimental Neurology (Division)
Member
From1 Oct 2000 → 31 Dec 2011
Projects
1 - 10 of 49
- Towards mechanistic biomarkers for amyotrophic lateral sclerosisFrom1 Jan 2024 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mapping the microglial heterogeneity in C9orf72-ALS and sporadic ALS using single cell profilingFrom1 Nov 2023 → TodayFunding: BOF - postdoctoral mandates
- A multi-modal and longitudinal approach to study the neurobiological underpinnings of disease onset and progression in genetic ALS variants: from presymptomatic to symptomatic disease stages.From1 Oct 2023 → TodayFunding: FWO junior postdoctoral fellowship
- HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutationsFrom19 Apr 2023 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- Measuring brain activation non-invasively in freely moving healthy and neuropsychiatric human populations using functional near-infrared spectroscopy (fNIRS)From1 Jan 2023 → TodayFunding: BOF - scientific equipment program
- Investigating the role of cilia dysfunction in Amyotrophic Lateral SclerosisFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Mechanisms of motor neuron degeneration in amyotrophic lateral sclerosis (ALS): cell death pathways and/or aberrant communication between cell body and neuromuscular junctionsFrom1 Oct 2022 → TodayFunding: BOF - projects
- A multi-modal approach to study C9orf72-mediated diseaseFrom16 May 2022 → 15 May 2023Funding: BOF - postdoctoral mandates
- Biomarkers in asymptomatic carriers of ALS-related mutationsFrom1 Apr 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding lysosomal dysfunction in the frontotemporal dementiaamyotrophic lateral sclerosis spectrum of neurodegenerative disorders.From1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
Publications
11 - 20 of 341
- A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons(2023)
Authors: Jimmy Beckers, Dietmar Thal, Ludo Van Den Bosch, Philip Van Damme
- Genetic variability in sporadic amyotrophic lateral sclerosis(2023)
Authors: Philip Van Damme
Pages: 3760 - 3769 - Multiomics and machine-learning identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis(2023)
Authors: Pegah Masrori, Philip Van Damme
Pages: 3770 - 3782 - UNC13A in amyotrophic lateral sclerosis: from genetic association to therapeutic target(2023)
Authors: Koen Demaegd, Philip Van Damme
Pages: 649 - 656 - PRECISION ALS-an integrated pan European patient data platform for ALS(2023)
Authors: Philip Van Damme
Pages: 389 - 393 - Phytochemical profiling by UPLC-ESI-QTOF-MS of Commelina africana, widely used in traditional medicine in DR Congo(2023)
Authors: Philip Van Damme
Pages: 325 - 334 - CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity(2023)
Authors: Wenting Guo, Elke Braems, Pegah Masrori, Evelien Van Schoor, Maarten Jacquemyn, Sriram Balusu, Tine Tricot, Pieter Vanden Berghe, Dietmar Thal, Rik Vandenberghe, et al.
Pages: 1245 - 1259 - Large-scale analyses of CAV1 and CAV2 suggest their expression is higher in post-mortem ALS brain tissue and affects survival(2023)
Authors: Philip Van Damme
- Differences in Cerebral Glucose Metabolism in ALS Patients with and without C9orf72 and SOD1 Mutations(2023)
Authors: Joke De Vocht, Fouke Ombelet, Pegah Masrori, Hilde Van Esch, Michel Koole, Patrick Dupont, Koen Van Laere, Philip Van Damme
- Whole genome sequencing analysis reveals post-zygotic mutation variability in monozygotic twins discordant for amyotrophic lateral sclerosis(2023)
Authors: Philip Van Damme
Pages: 76 - 87