Researcher
Wenting Guo
- Disciplines:Systems biology, Biochemistry and metabolism, Medical biochemistry and metabolism
Affiliations
- Biochemistry, Molecular and Structural Biology (Division)
Member
From1 Jun 2022 → 31 Dec 2022 - Stem Cell and Developmental Biology (Division)
Member
From1 Oct 2017 → 31 May 2022 - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Oct 2013 → 30 Sep 2017
Projects
1 - 1 of 1
- Pooled CRISPR/Cas9 screen in human stem cell-derived motor neurons to identify new therapeutic targets for amyotrophic lateral sclerosis (ALS)From1 Oct 2018 → 30 Sep 2019Funding: BOF - postdoctoral mandates
Publications
1 - 10 of 22
- CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity(2023)
Authors: Wenting Guo, Elke Braems, Pegah Masrori, Evelien Van Schoor, Maarten Jacquemyn, Sriram Balusu, Tine Tricot, Pieter Vanden Berghe, Dietmar Thal, Rik Vandenberghe, et al.
Pages: 1245 - 1259 - C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility(2021)
Authors: Laura Fumagalli, Mathias De Decker, Raheem Fazal, Wenting Guo, Jimmy Beckers, Koen Poesen, Pieter Vanden Berghe, Dietmar Thal, Catherine Verfaillie, Ludo Van Den Bosch, et al.
- HDAC6 inhibition restores TDP-43 pathology and axonal transport defects in human motor neurons with TARDBP mutations(2021)
Authors: Raheem Fazal, Mathias De Decker, Laura Fumagalli, Joni Vanneste, Wenting Guo, Ruben Boon, Thomas Vercruysse, Bart Swinnen, Jimmy Beckers, Pieter Vanden Berghe, et al.
- The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications(2020)
Authors: Wenting Guo, Jolien Steyaert, Ludo Van Den Bosch
Pages: 1651 - 1673 - CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model(2020)
Authors: Wenting Guo, Robert Ciarán Prior, Ludo Van Den Bosch
- Axonal transport defects and neurodegeneration: Molecular mechanisms and therapeutic implications(2020)
Authors: Wenting Guo, Katarina Dittlau, Ludo Van Den Bosch
Pages: 133 - 150 - RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease(2019)
Authors: Wenting Guo, Ludo Van Den Bosch
- Differentiation but not ALS mutations in FUS rewires motor neuron metabolism(2019)
Authors: Tijs Vandoorne, Koen Veys, Wenting Guo, Ann Swijsen, Matthieu Moisse, Guy Eelen, Laura Fumagalli, Raheem Fazal, Christine Germeys, Sarah-Maria Fendt, et al.
- Altered calcium dynamics and glutamate receptor properties in iPSC-derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations(2019)
Authors: Wenting Guo, Ludo Van Den Bosch
Pages: 2835 - 2850 - De novo ITPR1 variants are a recurrent cause of early-onset ataxia, acting via loss of channel function(2018)
Authors: Wenting Guo
Pages: 1623 - 1634
Patents
1 - 1 of 1
- Nek6 inhibition to treat als and ftd (Inventor)