Researcher
Olivier Vanakker
- Keywords:paediatric genetics, soft tissue mineralisation, syndromology, molecular genetics, pathophysiological mechanisms, calcification diseases, pseudoxanthoma elasticum, clinical genetics, dysmorphology, ectopic mineralisation diseases, stroke, cerebrovascular diseases
- Disciplines:Paediatrics and neonatology not elsewhere classified, Clinical genetics and molecular diagnostics, Neonatology, Epigenetics, Immunogenetics, Paediatrics, Genetics
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2003 → 30 Sep 2018
Projects
1 - 9 of 9
- International thematic network INTEC (ectopic calcifiaction)From1 Jan 2023 → TodayFunding: BOF - mobility
- Study of DDR/PARP1 signaling in the pathogenesis and treatment of soft tissue mineralization, using pseudoxanthoma elasticum as a model.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- An integrated translational platform to improve the management and outcome of rare heritable connective tissue diseaseFrom1 Jan 2021 → TodayFunding: BOF - projects
- Identifying mechanisms of disease variability in soft tissue mineralization disorders, using pseudoxanthoma elasticum as a modelFrom1 Jan 2021 → TodayFunding: FWO research project (including WEAVE projects)
- Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model.From1 Nov 2020 → 30 Sep 2023Funding: FWO fellowships
- Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model.From1 Oct 2019 → 31 Oct 2020Funding: BOF - doctoral mandates
- An integrated approach towards understanding and treating soft tissue mineralization, with pseudoxanthoma elasticum as a model.From1 Jan 2015 → 31 Oct 2019Funding: BOF - Doctoral projects
- Unraveling the ophthalmological phenotype and etiopathogenetic mechanisms in pseudoxanthoma elasticumFrom1 Oct 2014 → 30 Sep 2018Funding: FWO fellowships, BOF - Other initiatives
- Study of the cardiovascular phenotype and etiopathogenetic mechanisms in pseudoxanthoma elasticum.From1 Oct 2013 → TodayFunding: FWO fellowships
Publications
1 - 10 of 120
- Inorganic pyrophosphate plasma levels are decreased in pseudoxanthoma elasticum patients and heterozygous carriers but do not correlate with the genotype or phenotype(2023)
Authors: Matthias Van Gils, Justin Depauw, Shana Verschuere, Lukas Nollet, Olivier Vanakker
- The pseudoxanthoma elasticum zebrafish model contributes to novel pathophysiological insights and therapeutic strategies in ectopic mineralization(2023)
Authors: Lukas Nollet, Olivier Vanakker
Number of pages: 1 - The activation of JAK/STAT3 signaling and the complement system modulate inflammation in the primary human dermal fibroblasts of PXE patients(2023)
Authors: Christopher Lindenkamp, Ricarda Pluemers, Michel R. Osterhage, Olivier Vanakker, Judith Van Wynsberghe, Cornelius Knabbe, Doris Hendig
- Significance of premature vertebral mineralization in zebrafish models in mechanistic and pharmaceutical research on hereditary multisystem diseases(2023)
Authors: Judith Van Wynsberghe, Olivier Vanakker
- HRAS-related epidermal nevus syndromes : expansion of the spectrum with first branchial arch defects(2023)
Authors: Aude Beyens, Charlotte Lietaer, Kathleen Claes, Elfride De Baere, Marleen Goeteyn, Bob Lerut, Hannes Syryn, Olivier Vanakker, Joni Van der Meulen, Lieve Vanwalleghem, et al.
Pages: 709 - 713 - Various vascular malformations are prevalent in Finnish pseudoxanthoma elasticum (PXE) patients : a national registry study(2022)
Authors: Saku Pelttari, Suvi Vaaramaki, Olivier Vanakker, Hannu Uusitalo, Heini Huhtala, Tero Hinkka, Ilkka Porsti, I Nevalainen, Pasi
- Serum calcification propensity T50 associates with disease severity in patients with pseudoxanthoma elasticum(2022)
Authors: Lukas Nollet, Matthias Van Gils, Suzanne Fischer, Swapna Karthik, Andreas Pasch, Julie De Zaeytijd, Daniel Devos, Olivier Vanakker
- Minocycline counteracts ectopic calcification in a murine model of pseudoxanthoma elasticum(2022)Volume: 236
Authors: Elise Bouderlique, Lukas Nollet, Ellie Tang, Jeremy Zaworski, Letavernier Emmanuel, Olivier Vanakker
Number of pages: 1 - Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum(2022)
Authors: Lukas Nollet, Matthias Van Gils, Andy Willaert, Paul Coucke, Olivier Vanakker
Pages: 1629 - 1638.e6 - The pathogenic c.1171A>G (p.Arg391Gly) and c.2359G>A (p.Val787Ile) ABCC6 variants display incomplete penetrance causing pseudoxanthoma elasticum in a subset of individuals(2022)
Authors: Flora Szeri, Agnes Miko, Nastassia Navasiolava, Ambrus Kaposi, Beatrix Molnar, Qiaoli Li, Sharon F. Terry, Federica Boraldi, Jouni Uitto, Koen van de Wetering, et al.
Pages: 1872 - 1881