Researcher
Linos Vandekerckhove
- Keywords:Long-non-coding, RNA, Interactome, HIV, HIV Cure, HIV reservoir, HIV animal models
- Disciplines:Virology, Transcription and translation, Cellular interactions and extracellular matrix
Affiliations
- Department of Internal Medicine and Pediatrics (Department)
Member
From1 Oct 2018 → Today - Department of Diagnostic Sciences (Department)
Member
From1 Oct 2018 → Today - Department of Internal medicine (Department)
Member
From1 Oct 2010 → 30 Sep 2018 - Department of Clinical chemistry, microbiology and immunology (Department)
Member
From1 Oct 2008 → 30 Sep 2018
Projects
1 - 10 of 37
- Generation of a dynamic spatial map of the cellular landscape of HIV-infected gut and its application in unraveling the role of tissue-resident T cells in HIVFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- HIV Nanoheroes: novel CRISPR/Cas9-based CD4+ cell-specific HHV-7 vectors to cure HIVFrom1 Nov 2023 → TodayFunding: FWO Strategic Basic Research Grant
- Selection and Evolution of HIV-1 reservoir cells in blood and tissues - YEAR 3From1 Sep 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Defining molecular pathways triggered by IL-10 and TGFb that drive HIV integrationand persistence in Tfh cells in lymph nodesFrom1 Jul 2023 → TodayFunding: Other international institutions, not mentioned elsewhere
- Feasibility evaluation of anti-HIV Antibody-secreting Chimeric Antigen Receptor T cells as a potential cure in acute seroconvertersFrom30 Mar 2023 → 29 Mar 2024Funding: Foreign public sponsor
- Functional analysis of T cells infiltrating the lungs of severely ill COVID-19 patientsFrom1 Jan 2023 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- ABSL3 mice housing system to develop new therapies against virulent pathogensFrom15 Dec 2022 → TodayFunding: BOF - scientific equipment program
- How do ILCs go wrong: unravelling the mechanisms of ILC depletion and functions in HIV infectionFrom1 Nov 2022 → TodayFunding: FWO fellowships
- A novel CRISPR/Cas9-based nanomedicine strategy targeting CD4+ cells to cure HIVFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
- HIV-1 DNA based enrichment of intact proviruses: finding a helix in a haystackFrom1 Nov 2022 → TodayFunding: FWO Strategic Basic Research Grant
Publications
41 - 50 of 132
- Long non-coding RNAs and latent HIV : a search for novel targets for latency reversal(2019)
Authors: Wim Trypsteen, Cory H White, Amey Mukim, Celsa A Spina, Ward De Spiegelaere, Steve Lefever, Vicente Planelles, Alberto Bosque, Christopher H Woelk, Linos Vandekerckhove, et al.
- Gold nanoparticle-mediated photoporation enables delivery of macromolecules over a wide range of molecular weights in human CD4+ T cells(2019)
Authors: Laurens Raes, Clarissa Van Hecke, Julie Michiels, Stephan Stremersch, Juan Fraire, Toon Brans, Ranhua Xiong, Stefaan De Smedt, Linos Vandekerckhove, Koen Raemdonck, et al.
- Dolutegravir plus lamivudine versus dolutegravir plus tenofovir disoproxil fumarate and emtricitabine in antiretroviral-naive adults with HIV-1 infection (GEMINI-1 and GEMINI-2) : week 48 results from two multicentre, double-blind, randomised, non-inferiority, phase 3 trials(2019)
Authors: Pedro Cahn, Juan Sierra Madero, José Ramón Arribas, Andrea Antinori, Roberto Ortiz, Amanda E Clarke, Chien-Ching Hung, Jürgen K Rockstroh, Pierre-Marie Girard, Jörg Sievers, et al.
Pages: 143 - 155 - Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER) : final results of a multicentre, prospective, observational study(2019)
Authors: Alison J Rodger, Valentina Cambiano, Tina Bruun, Pietro Vernazza, Simon Collins, Olaf Degen, Giulio Maria Corbelli, Vicente Estrada, Anna Maria Geretti, Apostolos Beloukas, et al.
Pages: 2428 - 2438 - Establishing a hepatitis C continuum of care among HIV/hepatitis C virus-coinfected individuals in EuroSIDA(2019)
Authors: S. Amele, L. Peters, M. Sluzhynska, A. Yakovlev, A. Scherrer, P. Domingo, J. Gerstoft, J. P. Viard, M. Gisinger, R. Flisiak, et al.
Pages: 264 - 273 - Decreased NEAT1 and MALAT1 levels in HIV-1 positive individuals with high viral load(2019)
Authors: Clarissa Van Hecke, Sabine Kinloch-de Loes, Tinus Schynkel, Eva Malatinková, Sofie Rutsaert, Wim Trypsteen, Linos Vandekerckhove
Number of pages: 1 - HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs(2019)
Authors: Marie-Angélique De Scheerder, Bram Vrancken, Simon Dellicour, Timothy Schlub, Eunok Lee, Wei Shao, Sofie Rutsaert, Chris Verhofstede, Tessa Kerre, Thomas Malfait, et al.
Pages: 347 - 358 - Week 96 efficacy and safety results of the phase 3, randomized EMERALD trial to evaluate switching from boosted-protease inhibitors plus emtricitabine/tenofovir disoproxil fumarate regimens to the once daily, single-tablet regimen of darunavir/cobicistat/emtricitabine/tenofovir alafenamide (D/C/F/TAF) in treatment-experienced, virologically-suppressed adults living with HIV-1(2019)
Authors: Joseph J Eron, Chloe Orkin, Douglas Cunningham, Federico Pulido, Frank A Post, Stéphane De Wit, Erkki Lathouwers, Veerle Hufkens, John Jezorwski, Romana Petrovic, et al.
- Incidence of cancer and overall risk of mortality in individuals treated with raltegravir-based and non-raltegravir-based combination antiretroviral therapy regimens(2018)
Authors: A Cozzi-Lepri, R Zangerle, L Machala, K Zilmer, M Ristola, C Pradier, O Kirk, H Sambatakou, G Faetkenheuer, I Yust, et al.
Pages: 102 - 117 - Abacavir usage patterns and hypersensitivity reactions in the EuroSIDA cohort(2018)
Authors: A Roen, K Laut, A Pelchen-Matthews, E Borodulina, L Caldeira, A Clarke, B Clotet, A d'Arminio Monforte, G Fätkenheuer, JM Gatell Artigas, et al.
Pages: 252 - 260
Patents
1 - 1 of 1