Researcher
Leonie Wyffels
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Molecular Imaging and Radiology (MIRA) (Research group)
Member
From1 Jan 2019 → 30 Sep 2019 - Molecular Imaging, Pathology, Radiotherapy & Oncology (MIPRO) (Research group)
Member
From1 Feb 2012 → 31 Dec 2018
Projects
1 - 7 of 7
- Development of novel TCO probes for pretargeted intracellular PET imaging.From1 Oct 2018 → 31 Oct 2019Funding: BOF - Other initiatives
- Development of novel cell death PET imaging probes for early treatment response assessment.From1 Oct 2018 → 30 Sep 2022Funding: BOF - Doctoral projects
- Development of a caspase-3 selective activity-based probe for PET imaging of apoptosisFrom1 Apr 2016 → 31 Mar 2017Funding: BOF - Other initiatives
- Development of 18F-poly(2-oxazoline)-duramycin and 18Fpoly( 2-oxazoline)-RGD as radiotracers for in vivo imaging of tumor environment.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project (including WEAVE projects)
- Poxylation as next generation Pegylation.From1 Feb 2013 → 31 Jan 2014Funding: SBO (Strategic basic research)
- PET and SPECT imaging of protease activity by activitybased probes.From1 Jan 2013 → 31 Dec 2016Funding: FWO research project (including WEAVE projects)
- Immuno-positron emission tomography as a potential biomarker for diagnosis and treatment in Alzheimer disease.From1 Apr 2012 → 31 Mar 2014Funding: IWT / VLAIO - indirect funding by business world
Publications
31 - 40 of 73
- Phosphatidylethanolamine targeting for cell death imaging in early treatment response evaluation and disease diagnosis(2017)
Authors: Sigrid Stroobants, Leonie Wyffels
Pages: 971 - 987 - Evaluation of small-animal PET outcome measures to detect disease modification induced by BACE inhibition in a transgenic mouse model of Alzheimer disease(2017)
Authors: Steven Deleye, Ann-Marie Waldron, Jeroen Verhaeghe, Astrid Bottelbergs, Leonie Wyffels, Bianca Van Broeck, Xavier Langlois, Mark Schmidt, Sigrid Stroobants, Steven Staelens
Pages: 1977 - 1983 - The label matters(2017)
Authors: Mathias Glassner, Luca Palmieri, Bryn D. Monnery, Thomas Verbrugghen, Steven Deleye, Sigrid Stroobants, Steven Staelens, Leonie Wyffels, Richard Hoogenboom
Pages: 96 - 102 - Evaluation of [$^{18}F$]BR420 and [$^{18}F$]BR351 as radiotracers for MMP-9 imaging in colorectal cancer(2017)
Authors: Naiara Vázquez, Stephan Missault, Christel Vangestel, Steven Deleye, David Thomae, Pieter Van Der Veken, Koen Augustyns, Steven Staelens, Stefanie Dedeurwaerdere, Leonie Wyffels
Pages: 69 - 79 - $^{99m}Tc$-Duramycin SPECT imaging of early tumor response to targeted therapy(2017)
Authors: Jan Boddaert, Christel Vangestel, Koon Pak, Brian Gray, Samir Kumar-Singh, Steven Staelens, Sigrid Stroobants, Leonie Wyffels
Pages: 665 - 670 - Longitudinal characterization of [$^{18}F$]-FDG and [$^{18}F$]-AV45 uptake in the double transgenic TASTPM mouse model(2017)
Authors: Ann-Marie Waldron, Leonie Wyffels, Jeroen Verhaeghe, Jill C. Richardson, Mark Schmidt, Sigrid Stroobants, Xavier Langlois, Steven Staelens
Pages: 1537 - 1548 - Validation of the semi-quantitative static SUVR method for $^{18}F-AV45$ PET by pharmacokinetic modeling with an arterial input function(2017)
Authors: Julie Ottoy, Jeroen Verhaeghe, Ellis Niemantsverdriet, Leonie Wyffels, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Steven Deleye, Tobi Van den Bossche, et al.
Pages: 1483 - 1489 - The cerebrospinal fluid Aβ1-42/Aβ1-40 ratio improves concordance with Amyloid-PET for diagnosing Alzheimer's Disease in a clinical setting(2017)
Authors: Ellis Niemantsverdriet, Julie Ottoy, Charisse Somers, Ellen De Roeck, Hanne Struyfs, Femke Soetewey, Jeroen Verhaeghe, Tobi Van den Bossche, Sara Van Mossevelde, Johan Goeman, et al.
Pages: 561 - 576 - Preclinical evaluation of [$^{111}In$]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity(2016)
Authors: Christel Vangestel, David Thomae, Jeroen Van Soom, Johan Ides, Leonie Wyffels, Patrick Pauwels, Sigrid Stroobants, Pieter Van Der Veken, Viktor Magdolen, Jurgen Joossens, et al.
Pages: 448 - 458 - [18F]-FDG PET neuroimaging in rats with quinpirole-induced checking behavior as a model for obsessive compulsive disorder(2016)
Authors: Stijn Servaes, Dorien Glorie, Jeroen Verhaeghe, Leonie Wyffels, Sigrid Stroobants, Steven Staelens
Pages: 31 - 38