Researcher
David Thomae
- Keywords:Pharmacy and pharmacology
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal chemistry, Medicinal products, Pharmaceutical analysis and quality assurance, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences, Other medical and health sciences
Affiliations
- Medicinal Chemistry (UAMC) (Research group)
Member
From1 Jan 2012 → 16 Feb 2016
Projects
1 - 5 of 5
- Evaluation of the role of phosphodiesterase 7 and 10 in obsessivecompulsive disorders by positron emission tomography.From1 Oct 2015 → 15 Feb 2016Funding: FWO fellowships
- Synthesis and evaluation of radioligands for PDE7 imaging in addiction animal modelFrom1 Feb 2015 → 31 Dec 2015Funding: BOF - Other initiatives
- Design, Synthesis and evaluation of new potent radioligands for PDE7 imaging in the brain and implication of PDE7 in neurological disorders.From1 Jan 2015 → 16 Feb 2016Funding: FWO research grant KAN
- Design, synthesis and evaluation of new potent radioligands for PDE7 imaging in the brain.From1 Feb 2013 → 31 Dec 2013Funding: BOF - Other initiatives
- Design, synthesis and evaluation of new potent radioligands for PDE7 imaging and implication of PDE7 in neurological disorders.From1 Oct 2012 → 30 Sep 2015Funding: FWO Pegasus Marie Curie Fellowships
Publications
1 - 10 of 26
- Noninvasive relative quantification of $\left[^{11}C\right]$ABP688 PET imaging in mice versus an input function measured over an arteriovenous shunt(2018)
Authors: Jeroen Verhaeghe, Lauren Kosten, David Thomae, Marleen Verhoye, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
- MR-based spatial normalization improves [$^{18}F$]MNI-659 PET regional quantification and detectability of disease effect in the Q175 mouse model of Huntington's disease(2018)
Authors: Jeroen Verhaeghe, Lauren Kosten, David Thomae, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
- Longitudinal characterization of mGluR5 using $^{11}C$-ABP688 PET imaging in the Q175 mouse model of Huntington's disease(2018)
Authors: Lauren Kosten, Jeroen Verhaeghe, David Thomae, Leonie Wyffels, Sigrid Stroobants, John Wityak, Celia Dominguez, Ladislav Mrzljak, Steven Staelens
Pages: 1722 - 1727 - Evaluation of [$^{18}F$]fluorothymidine as a biomarker for early therapy response in a mouse model of colorectal cancer(2017)
Authors: Sara Rapic, Christel Vangestel, Jeroen Verhaeghe, David Thomae, Patrick Pauwels, Tim Van den Wyngaert, Steven Staelens, Sigrid Stroobants
Pages: 109 - 119 - Decreased levels of active uPA and KLK8 assessed by $\left[^{111}In\right]$MICA-401 binding correlate with the seizure burden in an animal model of temporal lobe epilepsy(2017)
Authors: Stephan Missault, Lore Peeters, Halima Amhaoul, David Thomae, Annemie Van Eetveldt, Barbara Favier, Anagha Thakur, Jeroen Van Soom, Asla Pitkanen, Koen Augustyns, et al.
Pages: 1615 - 1625 - Evaluation of [$^{18}F$]BR420 and [$^{18}F$]BR351 as radiotracers for MMP-9 imaging in colorectal cancer(2017)
Authors: Naiara Vázquez, Stephan Missault, Christel Vangestel, Steven Deleye, David Thomae, Pieter Van Der Veken, Koen Augustyns, Steven Staelens, Stefanie Dedeurwaerdere, Leonie Wyffels
Pages: 69 - 79 - Preclinical evaluation of [$^{111}In$]MICA-401, an activity-based probe for SPECT imaging of in vivo uPA activity(2016)
Authors: Christel Vangestel, David Thomae, Jeroen Van Soom, Johan Ides, Leonie Wyffels, Patrick Pauwels, Sigrid Stroobants, Pieter Van Der Veken, Viktor Magdolen, Jurgen Joossens, et al.
Pages: 448 - 458 - Multiprobe molecular imaging of an NMDA receptor hypofunction rat model for glutamatergic dysfunction(2016)
Authors: Lauren Kosten, Jeroen Verhaeghe, Robert Verkerk, David Thomae, Livia De Picker, Leonie Wyffels, Annemie Van Eetveldt, Stefanie Dedeurwaerdere, Sigrid Stroobants, Steven Staelens
Pages: 1 - 11 - Synthesis and preclinical evaluation of an $^{18}F$ labeled PDE7 inhibitor for PET neuroimaging(2015)
Authors: David Thomae, Stijn Servaes, Naiara Vázquez, Leonie Wyffels, Stefanie Dedeurwaerdere, Pieter Van Der Veken, Jurgen Joossens, Koen Augustyns, Sigrid Stroobants, Steven Staelens
Pages: 975 - 981 - Synthesis and in vivo preclinical evaluation of a $^{18}F$ labeled uPA inhibitor as a potential PET imaging agent(2014)
Authors: Johan Ides, David Thomae, Leonie Wyffels, Christel Vangestel, Jonas Messagie, Jurgen Joossens, Filip Lardon, Pieter Van Der Veken, Koen Augustyns, Sigrid Stroobants, et al.
Pages: 477 - 487