Researcher
Joleen Masschelein
- Disciplines (Flanders Institute for Biotechnology):Auto-ecology, Biogeography and phylogeography, Anthropological genetics, Bacteriology, Biogeochemical cycli, Epigenomics
- Disciplines (KU Leuven):Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Biotechnology of Plants and Micro-organisms (Division)
Member
From1 Aug 2020 → Today - Masschelein Lab (Research group)
Responsible
From1 Aug 2020 → Today - Animal and Human Health Engineering (A2H) (Division)
Member
From1 Aug 2020 → 30 Sep 2015 - Food and Microbial Technology (CLMT) (Division)
Member
From1 Aug 2020 → 15 Feb 2015 - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 2015 → 31 Jul 2020 - Division Animal and Human Health Engineering (Division)
Member
From1 Aug 2015 → 16 Apr 2018
Projects
1 - 10 of 25
- Purification, characterisation, and therapeutic potential of novel antimicrobial compounds from unidentified mouldFrom15 Jan 2024 → TodayFunding: IOF - mandates
- RePhactor - Phage-based biosynthetic gene cluster refactoring for the discovery and yield improvement of novel bioactive natural productsFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Charting the biosynthetic landscape of a novel class of bioactive specialized lipidsFrom18 Oct 2023 → TodayFunding: FWO fellowships
- COSMMOS: Characterising and Optimising the production flux of Secondary Metabolites in Clostridia using a hybrid Mechanistic machine learning multi-OmicS pipelineFrom18 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Metabolic Profiling of bioactive Antimicrobial Metabolites from Some of the selected Tanzanian Medicinal Plants: Bio-guided fractionation and Untargeted Metabolomics approaches.From7 Mar 2023 → TodayFunding: BOF - doctoral mandates
- Intrabacterial drug metabolism in Mycobacterium tuberculosisFrom9 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of Small-Molecule Inhibitors of FabV Effective in Gram-negative BacteriaFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- RiPPing through pathogenic bacteria and protein-protein interactionsFrom17 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- The bioactive microbiome - host protection on demandFrom8 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A microfluidic platform to screen engineered lasso peptides for therapeutic potentialFrom1 Nov 2021 → TodayFunding: FWO junior postdoctoral fellowship
Publications
11 - 20 of 23
- A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis.(2019)
Authors: Joleen Masschelein
Pages: 1 - 7 - Pentamycin biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-catalysed installation of the C-14 hydroxyl group.(2019)
Authors: Shanshan Zhou, Lijiang Song, Joleen Masschelein, Felaine AM Sumang, Irene A Papa, Teofila O Zulajbar, Aileen B Custodio, Daniel Zabala, Edwin P Alcantara, Emmanuel LC de los Santos, et al.
Pages: 1305 - 1309 - Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics(2017)
Authors: Joleen Masschelein, Rob Lavigne
Pages: 6196 - 6201 - Systematic analysis of the kalimantacin assembly line NRPS module using an adapted targeted mutagenesis approach(2016)
Authors: Birgit Uytterhoeven, Kenny Appermans, Joleen Masschelein, Thomas Lathouwers, Chris Michiels, Rob Lavigne
Pages: 279 - 286 - Minimum Information about a Biosynthetic Gene cluster(2015)
Authors: Joleen Masschelein, René De Mot, Rob Lavigne
Pages: 625 - 31 - The zeamine antibiotics: unusual polyamine-polyketide-nonribosomal peptide secondary metabolites from Serratia plymuthica RVH1(2015)
Authors: Joleen Masschelein, Rob Lavigne, Chris Michiels, Abram Aertsen
Number of pages: 175 - A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics(2015)
Authors: Joleen Masschelein, Charlien Clauwers, Karen Stalmans, Wesley Vermaelen, Eveline Lescrinier, Abram Aertsen, Chris Michiels, Rob Lavigne
Pages: 923 - 929 - The zeamine antibiotics affect the integrity of bacterial membranes(2015)
Authors: Joleen Masschelein, Charlien Clauwers, Karen Stalmans, Koen Nuyts, Wim De Borggraeve, Yves Briers, Abram Aertsen, Chris Michiels, Rob Lavigne
Pages: 1139 - 1146 - Genome sequence of Serratia plymuthica RVH1, isolated from a raw vegetable processing line(2014)
Authors: Abram Aertsen, Joleen Masschelein, Rob Lavigne, Chris Michiels
- A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis(2013)
Authors: Joleen Masschelein, Rob Lavigne
Pages: 685 - 92
Linked dataset
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