Researcher
Joleen Masschelein
- Disciplines (Flanders Institute for Biotechnology):Auto-ecology, Biogeography and phylogeography, Anthropological genetics, Bacteriology, Biogeochemical cycli, Epigenomics
- Disciplines (KU Leuven):Biomaterials engineering, Biological system engineering, Biomechanical engineering, Other (bio)medical engineering, Environmental engineering and biotechnology, Industrial biotechnology, Other biotechnology, bio-engineering and biosystem engineering
Affiliations
- Molecular Biotechnology of Plants and Micro-organisms (Division)
Member
From1 Aug 2020 → Today - Masschelein Lab (Research group)
Responsible
From1 Aug 2020 → Today - Animal and Human Health Engineering (A2H) (Division)
Member
From1 Aug 2020 → 30 Sep 2015 - Food and Microbial Technology (CLMT) (Division)
Member
From1 Aug 2020 → 15 Feb 2015 - Medicinal Chemistry (Rega Institute) (Division)
Member
From1 Oct 2015 → 31 Jul 2020 - Division Animal and Human Health Engineering (Division)
Member
From1 Aug 2015 → 16 Apr 2018
Projects
1 - 10 of 25
- Purification, characterisation, and therapeutic potential of novel antimicrobial compounds from unidentified mouldFrom15 Jan 2024 → TodayFunding: IOF - mandates
- RePhactor - Phage-based biosynthetic gene cluster refactoring for the discovery and yield improvement of novel bioactive natural productsFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Charting the biosynthetic landscape of a novel class of bioactive specialized lipidsFrom18 Oct 2023 → TodayFunding: FWO fellowships
- COSMMOS: Characterising and Optimising the production flux of Secondary Metabolites in Clostridia using a hybrid Mechanistic machine learning multi-OmicS pipelineFrom18 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Metabolic Profiling of bioactive Antimicrobial Metabolites from Some of the selected Tanzanian Medicinal Plants: Bio-guided fractionation and Untargeted Metabolomics approaches.From7 Mar 2023 → TodayFunding: BOF - doctoral mandates
- Intrabacterial drug metabolism in Mycobacterium tuberculosisFrom9 Jan 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of Small-Molecule Inhibitors of FabV Effective in Gram-negative BacteriaFrom1 Oct 2022 → TodayFunding: FWO Strategic Basic Research Grant
- RiPPing through pathogenic bacteria and protein-protein interactionsFrom17 Sep 2022 → TodayFunding: FWO Strategic Basic Research Grant
- The bioactive microbiome - host protection on demandFrom8 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A microfluidic platform to screen engineered lasso peptides for therapeutic potentialFrom1 Nov 2021 → TodayFunding: FWO junior postdoctoral fellowship
Publications
1 - 10 of 22
- Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast(2024)
Authors: Charlotte Cautereels, Dries De Ruysscher, Jan Steensels, Anton Gorkovskiy, Joleen Masschelein, Kevin Verstrepen
- Artificial intelligence for natural product drug discovery(2023)
Authors: Doris van Bergeijk, Joleen Masschelein
Pages: 895 - 916 - Polyketide Synthase-Mediated O-Methyloxime Formation in the Biosynthesis of the Oximidine Anticancer Agents(2023)
Authors: Eveline Vriens, Dries De Ruysscher, Sofie Dekimpe, Gert Steurs, Ahmed Shemy, Dirk Daelemans, Wim De Borggraeve, Eveline Lescrinier, Joleen Masschelein
- Molecular investigation of the zeamine antibiotics from Serratia plymuthica RVH1(2022)
Authors: Sofie Dekimpe, Rob Lavigne, Joleen Masschelein
- Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis(2021)
Authors: Sofie Dekimpe, Joleen Masschelein
Pages: 1910 - 1937 - Genomics-Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism(2020)
Authors: Joleen Masschelein
Pages: 23145 - 23153 - Total Synthesis of Kalimantacin A(2020)
Authors: Rob Lavigne, Joleen Masschelein
Pages: 6349 - 6353 - The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis inStaphylococcus aureusby Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI(2020)
Authors: Michiel Vanmeert, Ling-Jie Gao, Eveline-Marie Lammens, Eveline Lescrinier, Rob Lavigne, Joleen Masschelein
Pages: 10549 - 10556 - Unravelling the biosynthesis and mode of action of specialized metabolites(2019)
Authors: Thomas Lathouwers, Rob Lavigne, Chris Michiels, Joleen Masschelein
- A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis.(2019)
Authors: Joleen Masschelein
Pages: 1 - 7
Linked dataset
1 - 1 of 1