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Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
21 - 26 of 26
- Structure-function relationship of bacterial hyperpolarization-activated pacemaker channels.From1 Jan 2010 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Structure determination of prokaryote ion channels.From1 Jan 2009 → 31 Dec 2012Funding: FWO research project (including WEAVE projects)
- The search for toxin-derived modulators of voltage-gated sodium channels and their in vivo effects in autoimmune encephalomyelitisFrom1 Nov 2008 → 28 Sep 2012Funding: Own budget, for example: patrimony, inscription fees, gifts
- Axonal conduction and injury in multiple sclerosis: modulation of sodium and potassium channels as novel therapeutic approach.From1 Oct 2008 → 31 Oct 2012Funding: Private funding of national origin - undefined
- Elucidation of drug leads present in the venom of the scorpion Mesobuthus eupeus for the treatment of neuropathic pain.From1 Jan 2008 → 31 Dec 2010Funding: BOF - Bilateral scientific cooperation
- Molecular structure-function analysis of a novel class of scorpion venom toxins blocking potassium channels.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project
Publications
1 - 10 of 302
- The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits(2024)
Authors: Steve Peigneur, Jan Tytgat
- Bombé, an undetermined substance that caused an outbreak of illicit drug use in Kinshasa, Democratic Republic of the Congo(2023)
Authors: Radu Corneliu Duca, Jan Tytgat, Benoit Nemery de Bellevaux
Pages: 1055 - 1058 - Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways(2023)
Authors: Steve Peigneur, Jan Tytgat
- Immunosuppressive effects of new thiophene-based KV1.3 inhibitors(2023)
Authors: Steve Peigneur, Jan Tytgat
- New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel(2023)
Authors: Jan Tytgat, Steve Peigneur
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channels(2023)
Authors: Dongchen An, Jan Tytgat, Steve Peigneur
- Structure-function relationship of new peptides activating human Nav1.1(2023)
Authors: Steve Peigneur, Jan Tytgat
- Heterologous expression of the α-Ktx Ts7 and its functional evaluation on Kv channels and CD4+T cell differentiation(2023)
Authors: Jan Tytgat
Pages: S230 - S230 - Methionine-isoleucine dichotomy at a key position in scorpion toxins inhibiting voltage-gated potassium channels(2023)
Authors: Steve Peigneur, Jan Tytgat
- Design of New Potent and Selective Thiophene-Based K(V)1.3 Inhibitors and Their Potential for Anticancer Activity (vol 14, 2595, 2022)(2023)
Authors: Steve Peigneur, Jan Tytgat