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Researcher
Jan Tytgat
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Toxicology and Pharmacology (Division)
Responsible
From1 Jan 2012 → Today - Toxicology and Pharmacology (Division)
Member
From1 Oct 1999 → Today
Projects
11 - 20 of 26
- Discovery of new leads modulating voltage gated potassium ion channels as emerging cancer targetsFrom1 Oct 2017 → 30 Sep 2019Funding: BOF - Bilateral scientific cooperation
- Structure-based discovery of positive allosteric modulators of the alpha7 nicotinic acetylcholine receptor as cognition enhancers.From1 Oct 2016 → 30 Sep 2018Funding: IOF - Industrial Research Fund
- Ionic Liquids as promising solvents for liquid-liquid microextractions in forensic toxicologyFrom25 Aug 2014 → 5 Jul 2018Funding: Own budget, for example: patrimony, inscription fees, gifts
- EAG1 as a target for the diagnosis and therapy in childhood tumors: in appearance and late effects.From1 Jan 2014 → 31 Dec 2017Funding: FWO research project
- EAG1 as a target for cancer diagnosis and therapy in pediatric tumors: from early to late effects.From1 Jan 2014 → 27 Feb 2018Funding: IWT personal funding - strategic basic research grants
- Conus venom research: a source for novel pharmaceuticals.From1 Jan 2013 → 30 Apr 2014Funding: BOF - Bilateral scientific cooperation
- Venomics and transcriptomics of Conus spp.: an untapped treasure for drug discovery.From1 Oct 2012 → 30 Sep 2016Funding: BOF - Other initiatives
- Molecular and Cellular Mechanisms of Electrical Excitability.From1 Apr 2012 → 31 Dec 2017Funding: IUAP-VII
- Alternative post-mortem forensic toxicology specimens: an in-depth study of xenobiotics detectable in bones.From1 Jan 2012 → 31 Dec 2017Funding: FWO research project
- Biocompatibility and cariogenicity of composite dental restorative materials.From1 Jan 2010 → 31 Dec 2013Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 302
- The Sobering Sting: Oleoyl Serotonin Is a Novel Stephanoconus Snail Venom-Derived Antagonist of Cannabinoid Receptors That Counteracts Learning and Memory Deficits(2024)
Authors: Steve Peigneur, Jan Tytgat
- Bombé, an undetermined substance that caused an outbreak of illicit drug use in Kinshasa, Democratic Republic of the Congo(2023)
Authors: Radu Corneliu Duca, Jan Tytgat, Benoit Nemery de Bellevaux
Pages: 1055 - 1058 - Histamine Receptors: Ex Vivo Functional Studies Enabling the Discovery of Hits and Pathways(2023)
Authors: Steve Peigneur, Jan Tytgat
- Immunosuppressive effects of new thiophene-based KV1.3 inhibitors(2023)
Authors: Steve Peigneur, Jan Tytgat
- New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel(2023)
Authors: Jan Tytgat, Steve Peigneur
- Targeting cannabinoid receptor signaling for drug discovery and characterization: A focus on CB1 and CB2 cannabinoid receptors and GIRK1/GIRK2 potassium channels(2023)
Authors: Dongchen An, Jan Tytgat, Steve Peigneur
- Structure-function relationship of new peptides activating human Nav1.1(2023)
Authors: Steve Peigneur, Jan Tytgat
- Heterologous expression of the α-Ktx Ts7 and its functional evaluation on Kv channels and CD4+T cell differentiation(2023)
Authors: Jan Tytgat
Pages: S230 - S230 - Methionine-isoleucine dichotomy at a key position in scorpion toxins inhibiting voltage-gated potassium channels(2023)
Authors: Steve Peigneur, Jan Tytgat
- Design of New Potent and Selective Thiophene-Based K(V)1.3 Inhibitors and Their Potential for Anticancer Activity (vol 14, 2595, 2022)(2023)
Authors: Steve Peigneur, Jan Tytgat