Researcher
Dirk Snyders
- Research Expertise:Electrophysiological analysis and Patch clamp.
- Keywords:STABLE CELL LINE GENERATION, PATCH-CLAMP, CHANNEL GATING, MOLECULAR CELL BIOLOGY OF ION CHANNELS, Biomedical sciences (incl. biochemistry)
- Disciplines:Medicinal and biomolecular chemistry, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Cardiac and vascular medicine, Neurosciences, Physiology, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
- Research techniques:- Electrophysiological analysis - Patch clamp
- Users of research expertise:Pharmaceutical industry.
Affiliations
- Experimental Neurobiology Unit (ENU) (Research group)
Member
From1 Oct 2021 → Today - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Responsible
From1 Jan 2020 → 30 Sep 2021 - Molecular, Cellular and Network Excitability (MCNE) (Research group)
Member
From1 Jan 2018 → 31 Dec 2019 - Molecular biophysics, physiology and pharmacology (Research group)
Responsible
From1 Oct 2003 → 31 Dec 2017
Projects
11 - 20 of 22
- Gating modulating peptide toxins of Shaker-type Kv1 channels derived from the sea anemone Bunodosoma cangicum and the sea snail Conus longurionis.From1 Oct 2013 → 30 Sep 2015Funding: FWO fellowships
- Research in the domain of molecular biophysics.From1 Mar 2013 → 28 Feb 2014Funding: Foundations, funds and other with scientific goal
- "Silent" voltage-gated K+ channel subunits: analysis of the molecular determinants of modulatory properties and electrically silent behavior and elucidation of the physiological role.From1 Oct 2012 → 30 Sep 2015Funding: FWO fellowships
- Molecular mechanisms of the interaction between neurotoxins and potassium and sodium channels.From1 Jan 2012 → 31 Dec 2015Funding: FWO research project (including WEAVE projects)
- Molecular mechanism and function of modulatory subunits of Kv channels.From1 Jan 2011 → 31 Dec 2014Funding: FWO research project (including WEAVE projects)
- Characterization of biological toxins on tension-sensitive K+ canals.From1 Jan 2010 → 31 Dec 2011Funding: IWT personal funding - specialisation scholarships
- Molecular mechanism of modulation of Kv channels by PIP2 and small peptide modulators.From1 Jan 2010 → 31 Dec 2011Funding: Research funding concerning international, bilateral and/or cultural agreements
- Molecular coupling between voltage sensing and gating in Kv-channels.From1 Jan 2008 → 31 Dec 2011Funding: BOF - Other initiatives
- Molecular mechanisms of voltage-dependent gating in potassium channels.From1 Jan 2008 → 31 Dec 2011Funding: FWO research project (including WEAVE projects)
- Interactions of silent Kv subunits and their role in DRG neurons.From1 Jan 2008 → 31 Dec 2009Funding: IWT personal funding - specialisation scholarships
Publications
1 - 10 of 54
- Clinical and functional characterisation of a recurrent KCNQ1 variant in the Belgian population(2023)
Authors: Ewa Sieliwonczyk, Maaike Alaerts, Eline Simons, Dirk Snyders, Aleksandra Nijak, Bert Vandendriessche, Dorien Schepers, Dogan Akdeniz, Emeline Van Craenenbroeck, Katleen Knaepen, et al.
Pages: 1 - 12 - Improved selection of zebrafish CRISPR editing by early next-generation sequencing based genotyping(2023)
Authors: Ewa Sieliwonczyk, Bert Vandendriessche, Charlotte Claes, Evy Mayeur, Maaike Alaerts, Philip Holmgren, Tycho Canter Cremers, Dirk Snyders, Bart Loeys, Dorien Schepers
Pages: 1 - 13 - Morpho-functional comparison of differentiation protocols to create iPSC-derived cardiomyocytes(2022)
Authors: Aleksandra Nijak, Eline Simons, Bert Vandendriessche, Dieter Van de Sande, Erik Fransen, Ewa Sieliwonczyk, Ilse Van Gucht, Emeline Van Craenenbroeck, Johan Saenen, Hein Heidbuchel, et al.
- Offsetting voltage-dependent Kv1.5 channel opening through charged residue substitutions on top of the first transmembrane segment(2022)
Authors: Joni G. Heymans, Nikola Z. Popovic, Evelyn Martinez Morales, Dirk Snyders, Alain Labro
Pages: 160 - 167 - The nonconducting W434F mutant adopts upon membrane depolarization an inactivated-like state that differs from wild-type Shaker-IR potassium channels(2022)
Authors: Laura Coonen, Evelyn Martinez Morales, Dieter Van de Sande, Dirk Snyders, D. Marien Cortes, Luis G. Cuello, Alain Labro
Pages: 1 - 11 - Suitability of hSC and hiPSC derived cardiomyocytes as in vitro cell model that represents the physiological conditions for cardiotoxicity screening(2021)
Authors: Dieter Van de Sande, Dirk Snyders, Alain Labro
Number of pages: 190 - Constitutive, basal, and beta-alanine-mediated activation of the human mas-related G protein-coupled receptor D induces release of the inflammatory cytokine IL-6 and is dependent on NF-kappa B signaling(2021)
Authors: Samuel Van Remoortel, Dirk Snyders, Alain Labro, Jean-Pierre Timmermans
- The resting membrane potential of hSC-CM in a syncytium is more hyperpolarised than that of isolated cells(2021)
Authors: Dieter Van de Sande, Ivan Kopljar, Maaike Alaerts, Ard Teisman, David J. Gallacher, Bart Loeys, Dirk Snyders, Luc Leybaert, Hua Rong Lu, Alain Labro
Pages: 239 - 252 - REPLY TO PISUPATI ET AL.: Evaluating single subunit counting data to find the correct stoichiometry(2020)
Authors: Lena Moeller, Glenn Regnier, Alain Labro, Dirk Snyders, Rikard Blunck
Pages: 29290 - 29291 - Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations(2020)
Authors: Lena Moller, Glenn Regnier, Alain Labro, Rikard Blunck, Dirk Snyders
Pages: 9365 - 9376