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Project

Molecular mechanism and function of modulatory subunits of Kv channels.

The overall goal of this project is to obtain novel insights in the molecular aspects of the association and interaction of KvS and KCNE subunits with the Kv2 and KCNQ1 subunits, respectively, using several complementary techniques to study protein-protein interaction, subcellular distribution and biophysical channel properties. Furthermore, we aim to determine the physiological role of Kv2/KvS heterotetrameric channels, using a transgenic model system (targeted deletion of Kv6.4).
Date:1 Jan 2011 →  31 Dec 2014
Keywords:ION CHANNELS, MOLECULAR BIOPHYSICS
Disciplines:Medicinal and biomolecular chemistry, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Neurosciences, Physiology, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing