Researcher
Alexandre Wohlkönig
- Keywords (Vrije Universiteit Brussel):Applied biological sciences, biotechnology
- Disciplines (Flanders Institute for Biotechnology):(Bio)molecular modelling and design, Analytical biochemistry, Medical biophysics
Affiliations
- Structural Biology Brussels (Research group)
Member
From1 Sep 2009 → Today - Steyaert Lab (Research group)
Member
From1 Jan 2017 → Today - Department of Bio-engineering Sciences (Department)
Member
From1 Jul 2012 → 23 Dec 2016 - Department of Bio-engineering Sciences (Department)
Member
From1 Jul 2012 → 23 Dec 2016 - Department of Bio-engineering Sciences (Department)
Member
From1 Sep 2009 → Today
Publications
11 - 20 of 24
- Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide(2015)
Authors: Velupillai Srikannathasan, Alexandre Wohlkönig, Anthony Shillings, Onkar Singh, Pan F Chan, Jianzhong Huang, Michael N Gwynn, Andrew P Fosberry, Paul Homes, Martin Hibbs, et al.
Pages: 1242-1246 - Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody(2014)
Authors: Sarah Triest, Alexandre Wohlkönig, Els Pardon, Jan Steyaert
Pages: 1504-1507 - Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches.(2014)
Authors: Baptiste Villemagne, Marion Flipo, Nicolas Blondiaux, C Crauste, S Malaquin, Frederic Leroux, Catherine Piveteau, Vincent Villeret, Priscille Brodin, BO Villoutreix, et al.
Pages: 4876–4888 - The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation(2014)
Authors: Jade Leiba, Séverine Carrère-Kremer, Nicolas Blondiaux, Martin Moune Dimala, Alexandre Wohlkönig, Alain R Baulard, Laurent Kremer, Virginie Molle
Pages: 1132-1138 - Expression, Purification, Characterization, and Solution NMR Study of Highly‐Deuterated Recombinant Yeast Cytochrome c Peroxidase with Enhanced Solubility(2013)
Authors: Alexandre Wohlkönig, Sameh Soror, Nico Van Nuland
Pages: 2166-2175 - High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing(2013)
Authors: Joëlle Huet, Emmanuel Jean Teinkela Mbosso, Sameh Soror, Franck Meyer, Yvan Looze, René Wintjens, Alexandre Wohlkönig
Pages: 2017-2026 - Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis(2012)
Authors: Marion Flipo, Nicolas Willand, Nathalie Lecat-Guillet, Candide Hounsou, Matthieu Desroses, Florence Leroux, Zoé Lens, Vincent Villeret, Alexandre Wohlkönig, René Wintjens, et al.
Pages: 6391-6402 - Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors(2012)
Authors: Marion Flipo, Matthieu Desroses, Nathalie Lecat-Guillet, Baptiste Villemagne, Nicolas Blondiaux, Florence Leroux, Catherine Piveteau, Vanessa Mathys, Marie Pierre Flament, Juergen Siepmann, et al.
Pages: 68-83 - Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand(2011)
Authors: Karen Van De Water, Sameh Soror, Alexandre Wohlkönig, Nico Van Nuland
Pages: 703-706 - Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance(2010)
Authors: Alexandre Wohlkönig, Pan F Chan, Andrew P Fosberry, Paul Homes, Jianzhong Huang, Michael Kranz, Vaughan R Leydon, Timothy J Miles, Neil D Pearson, Rajika L Perera, et al.
Pages: 1152-1153
Patents
1 - 7 of 7
- Positive allosteric modulators of the calcium-sensing receptor (Inventor)
- Methods to select for agents that stabilize protein complexes (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)
- Means and methods for selection of specific binders (Inventor)
- Methods to select agents that stabilize protein complexes (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)
- Nanobody exchange chromatography (Inventor)