Researcher
Alexandre Wohlkönig
- Keywords (Vrije Universiteit Brussel):Applied biological sciences, biotechnology
- Disciplines (Flanders Institute for Biotechnology):(Bio)molecular modelling and design, Analytical biochemistry, Medical biophysics
Affiliations
- Structural Biology Brussels (Research group)
Member
From1 Sep 2009 → Today - Steyaert Lab (Research group)
Member
From1 Jan 2017 → Today - Department of Bio-engineering Sciences (Department)
Member
From1 Jul 2012 → 23 Dec 2016 - Department of Bio-engineering Sciences (Department)
Member
From1 Jul 2012 → 23 Dec 2016 - Department of Bio-engineering Sciences (Department)
Member
From1 Sep 2009 → Today
Publications
1 - 10 of 24
- Nanobody Loop Mimetics Enhance Son of Sevenless 1-Catalyzed Nucleotide Exchange on RAS(2023)
Authors: K Van Holsbeeck, Baptiste Fischer, S Gonzalez, Charlène Gadais, Wim Versées, José Martins, Charlotte Martin, Alexandre Wohlkönig, Jan Steyaert, Steven Ballet
Pages: 1-6 - Downsizing Nanobodies: Towards CDR3 Loop Mimetics Modulating Intracellular Protein-Protein Interactions(2022)
Authors: Baptiste Fischer, S Gonzalez, Charlène Gadais, José C. Martins, Alexandre Wohlkönig
Pages: 141-142 - Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM(2021)
Authors: Tomasz Uchański, Simonas Masiulis, Baptiste Fischer, Valentina Kalichuk, Uriel López-Sánchez, Eleftherios Zarkadas, Miriam Weckener, Andrija Sente, Philip Ward, Alexandre Wohlkönig, et al.
Pages: 60-68 - Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity(2020)
Authors: Baptiste Villemagne, Arnaud Machelart, Ngoc Chau Tran, Marion Flipo, Martin Moune, Florence Leroux, Catherine Piveteau, Alexandre Wohlkönig, René Wintjens, Xue Li, et al.
Pages: 366-378 - Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility(2020)
Authors: Dong-Zi Yang, Guy Vandenbussche, Didier Vertommen, Damien Evrard, Romany Abskharon, Jean‐François Cavalier, Gilles Berger, Stéphane Canaan, Mohammad Khan, Sheng Zeng, et al.
Pages: 79-93 - A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2(2019)
Authors: Hugues Prevet, Martin Moune, Abdalkarim Tanina, Christian Kemmer, Adrien Herledan, Rosangela Frita, Alexandre Wohlkönig, Marilyne Bourotte, Baptiste Villemagne, Florence Leroux, et al.
Pages: 426-438 - A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR(2019)
Authors: Abdalkarim Tanina, Alexandre Wohlkönig, Sameh Soror, Marion Flipo, Baptiste Villemagne, Hugues Prevet, Benoit Déprez, Martin Moune, Hélène Perée, Franck Meyer, et al.
Pages: 248-258 - An improved yeast surface display platform for the screening of nanobody immune libraries(2019)
Authors: Tomasz Uchański, Thomas Zögg, Jie Yin, Daopeng Yuan, Alexandre Wohlkönig, Baptiste Fischer, Daniel M. Rosenbaum, Brian K Kobilka, Els Pardon, Jan Steyaert
Pages: 1-12 - Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2(2017)
Authors: Alexandre Wohlkönig, Han Remaut, Martin Moune, Abdalkarim Tanina, Franck Meyer, Matthieu Desroses, Jan Steyaert, Nicolas Willand, Alain R Baulard, René Wintjens
Pages: 403-408 - reverse resistance(2017)
Authors: Nicolas Blondiaux, Martin Moune, Matthieu Desroses, Rosangela Frita, Marion Flipo, Vanessa Mathys, Karine Soetaert, Mehdi Kiass, Vincent Delorme, Kamel Djaout, et al.
Pages: 1206-1211
Patents
1 - 7 of 7
- Positive allosteric modulators of the calcium-sensing receptor (Inventor)
- Methods to select for agents that stabilize protein complexes (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)
- Means and methods for selection of specific binders (Inventor)
- Methods to select agents that stabilize protein complexes (Inventor)
- Nanobody exchange chromatography (Inventor)
- Fusion proteins comprising a cytokine and scaffold protein (Inventor)