Researcher
Alejandro Sifrim
- Disciplines:Genetics, Systems biology, Molecular and cell biology, Medical imaging and therapy, Other paramedical sciences
Affiliations
- Laboratory of Multi-omic Integrative Bioinformatics (Division)
Responsible
From1 Sep 2020 → Today - Department of Human Genetics (Department)
Member
From1 Sep 2020 → Today - Dynamical Systems, Signal Processing and Data Analytics (STADIUS) (Division)
Member
From1 Aug 2020 → 16 Oct 2016 - Laboratory of Reproductive Genomics (Division)
Member
From17 Oct 2016 → 31 Aug 2020
Projects
1 - 10 of 17
- A Comprehensive Translational Research and Training Pipeline Harnessing Lipid Metabolism to Improve Prostate Cancer Management and Educate Young Researchers in Tackling Complex DiseaseFrom1 Jan 2024 → TodayFunding: BOF - projects
- Machine Learning for Single-Molecule and Single-cell Multiomics to Bridge Genotype and Phenotype.From17 Sep 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding vulnerability in ALS using multi-omicsFrom27 Jun 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- An AI-driven study of mRNA subcellular localization using highly-multiplexed super-resolution in situ transcriptomicsFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Single-cell and spatial multi-omics for biomedicineFrom1 Oct 2022 → TodayFunding: IOF - mandates
- Single-objective light sheet instrument for fast and highthroughput imaging of 3D tissueFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- COLUMBO: Engineered CRISPR toolbox for revolutionizing single-cell genome imaging in embryogenesis and oncologyFrom1 Oct 2021 → TodayFunding: BOF - projects
- Automated characterization of cellular morphology and subcellular expression patterns using spatial transcriptomics and deep neural networksFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Development of multimodal deep neural networks for spatial multi-omics data fusionFrom1 Oct 2021 → TodayFunding: FWO Strategic Basic Research Grant
- Disease Mechanisms in ALS [a Single Nuclei Sequencing Study of Patient-derived Material]From22 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 53
- Adipose tissue macrophage dysfunction is associated with a breach of vascular integrity in NASH.(2024)
Authors: Matthias Lannoo, Ellen Deleus, Baki Topal, Tessa Ostyn, Lena Smets, Lukas Van Melkebeke, Tania Roskams, Jef Verbeek, Olivier Govaere, Alejandro Sifrim, et al.
Pages: 397 - 408 - Large-scale data-driven analysis to understand the contribution of rare variants to congenital heart disease(2024)
Authors: Alejandro Sifrim, Jeroen Breckpot
Pages: 13 - 13 - Exome-based case-control study identifies NOTCH1 variants as the major monogenic cause of CHD(2024)
Authors: Jeroen Breckpot, Alejandro Sifrim
Pages: 422 - 422 - Differential alternative splicing analysis links variation in ZRSR2 to a novel type of oral-facial-digital syndrome(2023)
Authors: Catia Attanasio, Elise Pelgrims, Mio Aerden, Anne Rochtus, Ann Swillen, Alejandro Sifrim, Jeroen Breckpot
- The extracellular matrix dictates regional competence for tumour initiation(2023)
Authors: Alejandro Sifrim
- Pharmacological targeting of netrin-1 inhibits EMT in cancer(2023)
Authors: Alejandro Sifrim, Thierry Voet
Pages: 402 - + - Methods and applications for single-cell and spatial multi-omics(2023)
Authors: Katy Vandereyken, Alejandro Sifrim, Bernard Thienpont, Thierry Voet
Pages: 494 - 515 - Dedicated macrophages organize and maintain the enteric nervous system(2023)
Authors: Elodie Modave, Marcello Delfini, Nathalie Stakenborg, Tobie Martens, Katy Vandereyken, Alejandro Sifrim, Gianluca Matteoli, Pieter Vanden Berghe, Thierry Voet, Guy Boeckxstaens
Pages: 818 - 826 - Detecting cryptic clinically relevant structural variation in exome-sequencing data increases diagnostic yield for developmental disorders(2021)
Authors: Alejandro Sifrim
Pages: 2186 - 2194 - Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease(2021)
Authors: Jeroen Breckpot, Alejandro Sifrim, Koenraad Devriendt, Bernard Thienpont