Synthesis of bicyclic amine scaffolds via tandem catalysis.

Modern organic synthesis provides a toolbox of synthetic methods which (at least theoretically) allows to make every single organic molecule. However, the efficiency (overall yield, number of steps, resources and time required) obtained in a multistep synthesis is often (very) low. Considering the strive for greener organic syntheses and the need to access novel areas of 'chemical space', through molecular libraries targeting specific applications, 'efficiency improvement' is a key goal. In this context direct(ed) transition metal-catalyzed C-H bond functionalization is an important contemporary research field obviating the need to preinstall leaving groups in organic molecules. Indirect synthesis is still the standard procedure in organic synthesis. Another important field in the context of green synthesis is tandem catalysis, allowing to perform several transformations in one single step by orthogonal catalysts, where a first catalyst provides the substrate for the next catalytic cycle. This saves synthetic steps and time. In this project we want to combine both areas and develop tandem catalysis involving directed C-H functionalization.

Keywords:CATALYSIS

Disciplines:Organic chemical synthesis, Catalysis, Organic green chemistry