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Matthijs Vynck Ghent University
Kris De Jonghe Research Institute for Agriculture, Fisheries and Food
Nick Van Reet Institute of Tropical Medicine
Annelies Haegeman Research Institute for Agriculture, Fisheries and Food
Steve Lefever Ghent University
Computational Cancer Biology and Epigenomics KU Leuven
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Cancers are highly heterogeneous entities, both within a single tumor and across patients. Intratumoral heterogeneity stems from the spectrum of cancer cell clones and the dynamic cellular composition of the tumour microenvironment. Cross-patient heterogeneity is based on the multitude of cancer cells-of-origin and patient-specific combinations of germline and somatic genetic variants driving the tumorigenesis. Despite recent major ...