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Structural biology is a central discipline in molecular life sciences, and our Center for Structural Biology (CSB) has been a cornerstone of the research conducted at the VUB and the VIB, first under the leadership of Lode Wyns, and more recently under the guidance of Jan Steyaert and Han Remaut. The Center has made several top-tier discoveries, of which Nanobody technology has been running like a tread through the history of CSB. The centre ...

The Laboratory of Structural Neurobiology is interested in understanding the structural basis of ion channel function. Ion channels are integral membrane proteins that act as molecular switches of electrochemical signaling in the central nervous system. Our specific goal is to understand the structural determinants of ligand recognition, the mechanism of channel gating and ion selection and permeation. Our methodological approach is based on ...

The ULTR group was built around Lode Wyns and Serge Muyldermans who started investigating biomolecular structures in the 80's. The initial focus was a biochemical and biophysical analysis of chromatin assembly and structure, necessitating major efforts in the acquisition of the appropriate technological tools, including protein & nucleic acid chemistry, genetic engineering, analytical centrifugation and spectroscopy. In 1989, the long ...