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Laboratory of Structural Neurobiology


Lifecycle:1 Oct 2007 →  Today
Organisation profile:

The Laboratory of Structural Neurobiology is interested in understanding the structural basis of ion channel function. Ion channels are integral membrane proteins that act as molecular switches of electrochemical signaling in the central nervous system. Our specific goal is to understand the structural determinants of ligand recognition, the mechanism of channel gating and ion selection and permeation. Our methodological approach is based on electrophysiological techniques to understand function, in combination with structural methods such as X-ray crystallography and cryo-EM to understand structure. At present we are pursuing structures for various classes of ligand-gated ion channels, including the family of pentameric ligand-gated ion channels or Cys-loop receptors, TRP channels and CNG/HCN channels. Combined, our approach opens new avenues for structure-based design of new drugs to better treat disorders associated with abnormal ion channel function

Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing