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Laboratory for Molecular Cancer Biology (VIB-KU Leuven Center for Cancer Biology) KU Leuven

The research program of the Laboratory for Molecular Cancer Biology is devoted to the analysis of pathways governing the genesis, progression and maintenance of cancer.Our current research efforts follow from our recent studies on the p53 tumor suppressor. p53 is a transcription factor that functions as a central component of most cellular stress responses. The outcome of p53-mediated surveillance is closely dependent on the type of stress ...

Laboratory of Growth Control and Cancer Research (VIB-KU Leuven Center for Cancer Biology) KU Leuven

Responsible

The Laboratory of Growth Control and Cancer Research conducts reasearch on the mechanisms that control organ size. Currently they focus on three main topics: 1) How mechanical forces regulate cellular behavior and the Hippo pathway, 2) The regulation of cell competition and the role of the Hippo pathway therein, and 3) The role of the Hippo pathway in cancer cell dormancy. These three projects are highly related and interconnected and aim at ...

Laboratory for Mechanisms of Cell Transformation (VIB-KU Leuven Center for Cancer Biology) KU Leuven

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The research interests from the Laboratory for Mechanisms of Cell Transformation are focused on understanding the cooperative interactions that conspire to promote tumorigenic transformation. To discover drivers of cancer development and progression, they create experimental models of cell transformation derived from primary human cells that mimic alterations found in human cancer samples. These models provide a useful platform to delineate ...

Laboratory for Translational Breast Cancer Research KU Leuven

Responsible

Part of the Department of Oncology that fosters synergy in innovative oncological research. By creating a close link between bed and bench and by capitalizing on advanced technologies, our researchers aim to unravel key molecular mechanisms underlying the development and progression of cancer and to maximize opportunities to translate these findings into better clinical biomarkers, adaptive strategies and innovative treatments.

Laboratory of Cellular Metabolism and Metabolic Regulation (VIB-KU Leuven Center for Cancer Biology) KU Leuven

Responsible

The Laboratory of Cellular Metabolism and Metabolic Regulation is specifically interested in elucidating general regulatory principles in metabolism, understanding cancer metabolism and its implications for novel therapeutic interventions, and revealing the role of metabolism at the interface of metabolic syndrome disorders and cancer. We use mass spectrometry based metabolic flux analysis and metabolite profiling combined with genetic ...

Laboratory of Lipid Metabolism and Cancer KU Leuven

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The Laboratory of Lipid Metabolism and Cancer focusses on altered lipid metabolism in cancer cells. Using a state-of-the-art mass spectrometry-based lipidomics technology the group has made the intriguing observation that development and progression of cancer is almost invariably accompanied by dramatic changes in the cell’s composition of phospholipids. As phospholipids play a key role in the formation of membranes, which organize numerous ...

Laboratory of Endothelial Molecular Biology (VIB-KU Leuven Center for Cancer Biology) KU Leuven

(URL:http://www.kuleuven.be/wieiswie/en/unit/52576632)Laboratory of E ndothelial Molecular Biology (Vesalius Research Center).

The goal of the Laboratory of Endothelial Molecular Biology (VRC) is to expand the current knowledge of how metabolism regulates endothelial redox homeostasis and vice-versa in healthy and diseased conditions. To accomplish this they have taken advantage of the innovative genetic and imaging technology as well ...

Laboratory for Disease Mechanisms in Cancer KU Leuven

Responsible

The Laboratory for Disease Mechanisms in Cancer conducts research into the link between the ribosome and cancer. The research questionson wich the laboratory focuses are:

1) What is the spectrum of acquired ribosome defects in cancer?

2) By what mechanisms do ribosome defects promote cancer?

3) Are ribosome defects therapeutically relevant?