Projects
Influence of microstructural parameters on friction an wear mechanisms of electro discharge machined electrically conductive ceramic composites Ghent University
Correlations between microstructure of electrically conductive ceramics and electro discharge machining properties as well as tribological behavior: - Influence of ceramic phase on electrical and thermal properties and electromachining performance - Influence of ceramic phase on tribological properties - Influence of electromachining process of friction and wear behaviour - Influence of microstructure on thermal residual stress and ...
Understanding functioning and evolution of bird middle ear mechanics through high-realism finite element modelling and system identification. University of Antwerp
Understanding functioning and evolution of bird middle ear mechanics through high-realism finite element modelling and system identification Vrije Universiteit Brussel
Optical tomography and topography devices to study (patho)physiology and mechanics of the ear. University of Antwerp
Fundamental study on self-lubricating characteristics of polymer from the perspective of wear response, interfacial dynamics and the formation of transfer layer. Ghent University
Investigating particle generation and transfer layer dynamicity at micron-scale provides precise information on the polymer wear process. Parameters contributing specifically to mild, transition and severe wear are studied for its physical interaction process in continuous sliding using advanced image based in-situ monitoring of contact surface. Thereby understanding the complex self-protecting and lubricating nature of polymers.
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Mechanisms and evolution of mammalian hair color Ghent University
Color serves diverse functions in mammalian hairs, including crypsis, sexual display, and resistance to wear. Our understanding of the roles that these colors have played in mammalian evolution has been hindered by both a limited understanding of their mechanistic bases and a complete inability to know the colors of mammals known only from fossils. We therefore propose to collect data on melanin (and potentially other pigments) in extant ...
Toxin induced lysosomal storage disease: a new etiological, mechanistic, diagnostic and prognostic paradigm for the worldwide increasing prevalence of agrochemical-associated nephropathy. University of Antwerp
Deciphering Secretase mechanisms: providing the underpinnings for novel, rational-based therapeutic approaches KU Leuven
Alzheimer’s disease (AD) is progressive neurodegenerative disorder estimated to affect more than 150 million people by 2050. γ-Secretases (GSECs) are proteases which embedded in the membrane cut several substrates, including the amyloid precursor protein (APP). This cleavage process gained considerable scientific interest as more than 200 mutations in GSEC and around 20 in APP, cause early onset AD. We have recently found that AD-causing ...
Towards molecular control of electrophilic aromatic substitution reactions in homogeneous and heterogeneous environments through a combined ab initio molecular dynamics and conceptual density functional theory approach. Ghent University
The electrophilic aromatic substitution (SEAr) is a cornerstone reaction discovered by Friedel and
Crafts in the 19th century. Despite its industrial importance for ethylbenzene production, the
reaction mechanism is still debated. The proposed mechanistic pathway, relying on the formation of
arenium ion intermediates, was recently challenged on experimental and theoretical grounds. The
formation of the commonly assumed ...