Projects
Syndecan-PDZ scaffolds in the molecular and functional heterogeneity of extracellular vesicles: the role of syntenin in ncRNA transfer KU Leuven
Extracellular vesicles (EVs) emerge as organelles supporting cell-to-cell communication over short or long distances. They contribute to various physiological and pathological processes. They contribute to various systemic diseases, in particular cancer, neurodegeneration and pathogen invasion. EVs are limited by a lipid bilayer, and can be released by any type of cell. They have the same topology as the cell and contain a mixture of genetic ...
Generation of artificial nucleic acid system for biotechnology and therapeutics KU Leuven
* Artificial nucleic acid (XNA/DZA) blocks as bioengineering tools for construction of stable vectors and protection of cleavage sites.
* Fully substituted biopolymers (DNA and RNA) as templates for genetic information storage and transfer in living organisms (bacterial and mammalian cells).
* Design of stable non-immunogenic XNA-based therapeutics