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Quantitative proteomics reveals altered expression of actin binding proteins after LMNA knockdown in human dermal fibroblasts Ghent University
The nuclear lamina physically supports the cell nucleus and has a central role in gene regulation. Mutations in the LMNA gene, which encodes A-type lamins, cause a wide spectrum of tissue-specific and systemic diseases collectively called laminopathies. To elucidate the molecular mechanisms underlying this phenotypic diversity, we set out to identify changes in the proteome upon specific lamin perturbations. More specifically, mature lamin A was ...
Experimental design in quantitative proteomics Hasselt University
Metabolites and proteins are potential biomarkers. They can be identified with the help of mass spectrometry (MS). However, measurements obtained by using MS are prone to various random and systematic errors. The sensitivity of the technology to the errors poses practical challenges, including concerns about reproducibility of the MS-based assays and the possibility of false findings. Given the sensitivity, the proper design of MS-based ...
Rover: a tool to visualize and validate quantitative proteomics data from different sources Ghent University
Quantitative proteomics reveals differential effects of ZMPSTE24 and LMNA knockdown on human fibroblasts Ghent University
Quantitative proteomics to characterize specific histone H2A proteolysis in chronic lymphocytic leukemia and the myeloid THP-1 cell line Ghent University
Summarization vs. peptide-based models in label-free quantitative proteomics : performance, pitfalls, and data analysis guidelines Ghent University
Quantitative proteomics of pomegranate varieties with contrasting seed hardness during seed development stages Ghent University
Towards Building a Quantitative Proteomics Toolbox in Precision Medicine: A Mini-Review KU Leuven Hasselt University Ghent University
Precision medicine as a framework for disease diagnosis, treatment, and prevention at the molecular level has entered clinical practice. From the start, genetics has been an indispensable tool to understand and stratify the biology of chronic and complex diseases in precision medicine. However, with the advances in biomedical and omics technologies, quantitative proteomics is emerging as a powerful technology complementing genetics. Quantitative ...
Quantitative proteomics of rat and human pancreatic beta cells Vrije Universiteit Brussel
Data set description: This data set is composed by label-free alternate-scanning LC-MS/MS proteomics analysis human and Wistar rat pancreatic islet endocrine cells. The mass spectrometry data of the human and rat pancreatic beta cells and the resulting proteome search output from ProteinLynx GlobalSERVER (PLGS) have been deposited to the ProteomeXchange Consortium [1] via the PRIDE partner repository with the dataset identifiers PXD001539 ...