The hepatic progenitor cell niche under experimental conditions and in human liver disease Ghent University
The purpose of this research proposal is to study the morphology, function and cellular physiology of the progenitor cell niche in the normal and diseased liver. Local adult progenitor cell niches are special microenvironments that contain somatic progenitor cells (ASPCs). The latter are generally slow-cycling cells which give rise to transit amplifying cells (TACs) that leave the niche. TACs cycle faster than progenitor cells but have a ...
Hepatocytic differentiation of hepatic progenitor cells in acute and chronic hepatocytic human liver diseases. KU Leuven
The hepatic progenitor cell niche: under experimental conditions and in human liver disease KU Leuven
The hepatic progenitor cells (HPCs) are the stem cell-like cells of the liver. They are small, situated in the canals of Hering, and are characterized by a relative large oval nucleus and scanty cytoplasm. HPCs express both markers of (immature) hepatocytes (e.g. alpha-fetoprotein) and markers of cholangiocytes (e.g. cytokeratin K7 and K19) and can differentiate into cholangiocytes or hepatocytes. Nevertheless, the mechanisms behind ...
Paracrine and transcriptional regulation of renewal and differentiation of embryonic and adult multi-potent progenitor cells in vertebrates KU Leuven
Immunomodulatory actions of multipotent adult progenitor cells and myeloid-derived suppressor cells in T cell alloreactivity assays. Implications for immunomodulating cell therapy. KU Leuven
Bipotential progenitor cells to treat cardiac and skeletal muscle degeneration in a large animal model of Duchenne Muscular Dystrophy. KU Leuven
Duchenne Muscular Dystrophy (DMD) causes untreatable and progressive degeneration of cardiac and skeletal muscles. Cell therapies are emerging as curative approach to functionally regenerate damaged muscles, yet strategies to equally target both muscle types are still missing. Induced pluripotent stem cells (iPSCs) are raising new expectations in the field, given the unprecedented possibility of patient-matched cells virtually differentiating ...