Immunomodulatory actions of multipotent adult progenitor cells and myeloid-derived suppressor cells in T cell alloreactivity assays. Implications for immunomodulating cell therapy.

Cell-based therapy is becoming an important therapeutic tool in medicine and many research efforts are devoted to the exploration of various cell types for degenerative and immune-mediated diseases. One example is  mesenchymal stem cells to control graft-versus-host-disease, an important immune complication of allogeneic hematopoietic stem cell transplantation in the treatment of hematological malignancies. This research project aims to investigate the immune behavior and potential immunomodulatory actions of two novel progenitor cell types in experimental assays of graft-versus-host disease: mul</>tipotent adult progenitor cells</>, a mesenchym-derived progenitor cell with broad differentiation capacity that can be isolated from post-natal bone marrow and that may hold, similar to mesenchymal stem cells, immunomodulatory potential for graft-versus-host disease, and myeloid-derived suppressor cells</>, which are bone marrow-derived progenitor cells of myeloid origin that can suppress in vitro graft-versus-host responses and that have been shown in mice to expand in the setting of allogeneic hemaotpoietic stem cell transplantation.

Keywords:Immunomodulatory actions, Cell therapy

Disciplines:Urology and nephrology

Project type:PhD project