Vitamin D analogs in combination with palbociclib as treatment for triple-negative breast cancer – preclinical evaluation and pathway analysis KU Leuven
1,25(OH)2D3, the biological active form of vitamin D3, is an important regulator of calcium and phosphate homeostasis in the body. By binding to the vitamin D receptor (VDR) and subsequent heterodimerization with the retinoid X receptor (RXR), this complex will migrate to the nucleus and bind to vitamin D responsive elements (VDREs) in regulatory regions of target genes to regulate gene transcription. Next to calcium and phosphate ...