Projects
The Expression of Mitigation in Spanish-English Codeswitching Contexts. A Multifactorial and Multimethod Account. Ghent University
This project wants to contribute to a better understanding of the grammar underlying Spanish-English codeswitching phenomena. In concrete, it looks into the factors governing an overlooked but highly productive construction in codeswitching contexts, namely mitigation structures. These express quantitative or qualitative reduction of a base form, as in a little casa or the casita (‘the small house’). The construction is very differently ...
Focal activation of adenosine A1 receptor signaling in the hippocampus by means of photopharmacology: a possible tool for epileptic seizure suppression Ghent University
Temporal lobe epilepsy (TLE) is the most common form of drug-resistant epilepsy, often with a seizure focus in the hippocampus (HC). To treat this disorder, innovative therapies are needed. Adenosine is an endogenous nucleoside known to have potent seizure-suppressive effects in the brain. These effects are mediated by the activation of inhibitory adenosine A1 receptors (A1Rs). The HC is a structure with high A1R expression, making A1R ...
Mechanistic study of the activation of small molecules with transition metal active sites in zeolites KU Leuven
The activation of small molecules encompasses some of the most pressing challenges in catalysis. It relates to the upgrading of abundant molecules (O2, N2, CH4) for use in chemical industry, but also the remediation of malignant molecules (NOx, CO, greenhouse gases CO2, N2O, CH4). In this proposal I will use reactive oxygen species (ROS) in zeolites to achieve small molecule activation. Such zeolitic ROS are known on Cu and Fe exchanged ...
Balancing socio-economic and public health impact of COVID-19 for its sustainable control and mitigation (SOPHIA) Ghent University
Given the uncertainty about the further development of the COVID-19 pandemic, decision makers urgently need to balance the immediate public health impact of the virus and the - yet uninvestigated - psychological and socio-economic impacts of the mitigation measures that were imposed to safeguard our health care system. Just as the spread of COVID-19 itself, these effects are spatially heterogeneous and scale dependent, hence the need to ...
Study on the impact of Nlrp3 inflammasome activation in intra-epithelial lymphocytes on intestinal inflammation Ghent University
The Nlrp3 inflammasome is a protein complex responsible for mounting cytokine and cell death responses upon detecting microbial or host-derived stress signals. Nlrp3 variants are associated with Crohn’s Disease (CD) but the cellular origins of these detrimental Nlrp3 signaling effects have not been identified. While Nlrp3 is thought to be expressed only in innate immune cells I have data showing that also small intestinal intra-epithelial ...
Balancing socio-economic and public health impact of COVID-19 for its sustainable control and mitigation (SOPHIA) KU Leuven
Given the uncertainty about the further development of the
COVID-19 pandemie, decision makers urgently need to balance the immediate public health impact of
the virus and the - yet uninvestigated - psychological and socio-economic impacts of the mitigation
measures that were imposed to safeguard our health care system. Just as the spread of COVID-19
itself, these effects are spatially heterogeneous and scale dependent, ...
Public support for climate change mitigation and eco-social policies in Europe: the role of social justice considerations in legitimising and promoting the transition to low-carbon societies KU Leuven
In the face of accelerating global warming and attendant natural disasters, it seems that governments all over the world eventually have to take measures mitigating the most adverse consequences of climate change. However, such measures are likely to be opposed if they do not reflect public attitudes. To better understand attitudes towards climate change mitigation policies (CMP), and in particular what influences support of them, scholars ...
Exploring the potential and underlying mechanisms of therapeutic activation of p53 in combination with immunotherapy to stimulate an innate immune response against non-small cell lung cancer. University of Antwerp
Study of the molecular pathways through which linear (de)ubiquitination governs skin inflammation and aberrant epidermal stem cell activation Ghent University
Inflammatory signaling pathways need to be tightly regulated in order to avoid chronic inflammation and the development of inflammatory pathology One of the regulatory proteins responsible for such control is OTULIN, a deubiquitinating enzyme which specifically cleaves linear ubiquitin chains generated by the linear ubiquitin chain assembly complex
We have generated keratinocyte-specific OTULIN knockout mice which develop a severe ...