Projects
New ways to explore fundamentals of the formation of self-assembled molecular networks at the liquid-solid interface KU Leuven
The spontaneous organisation of molecules into ordered patterns or complex systems, i.e. self-assembly, emerges in nature and plays a crucial role in life. It enables the formation of intricate structures in biological membranes, guides DNA assembly, and directs protein folding. In supramolecular chemistry, rapid progress has sparked numerous possibilities for leveraging intermolecular interactions across various fields. The development of ...
Molecular imaging for early response assessment of drugs targeting the PI3K/mTOR pathway in an HER-2 amplified breast cancer model. University of Antwerp
Combining small animal molecular imaging with next generation neuromodulation to explore novel treatments for Obsessive Compulsive Disorder. University of Antwerp
Molecular Signaling in Cell Death and Inflamation: an integrative approach from basic mechanisms to disease models Ghent University
The P7/32 DISCOBEL network will focus on the interrelation between cell death and inflammation in an integrated approach going from the study of fundamental mechanisms in cell death, NF-kB and inflammasome to validation of concepts in inflammatory, infectious and cancer disease models and bringing them to experimental therapeutic applications in mice.
The main objectives of the DISCOBEL research program are:
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First principle molecular dynamics simulations for complex chemical transformations in nanoporous materials Ghent University
Chemical transformations in nanoporous materials are vital in many application domains, such as catalysis, molecular separations, sustainable chemistry,…. Model-guided design is indispensable to tailoring materials at the nanometer scale level. At real operating conditions, chemical transformations taking place at the nanometer scale have a very complex nature, due to the interplay of several factors such as the number of particles present in ...
Molecular characterization of Atrichum angustatum as novel model system to study vascular development and evolution Ghent University
Within the wide diversity of plant species on earth, a main distinction is made into vascular and non-vascular plants. However, the presence of conductive tissues is not a simple binary trait, as some non-vascular mosses do have conductive tissues which can be compared to those of vascular plants at the molecular level. We however have very little information on the molecular basis of the transition from non-vascular to vascular plants. ...
Design and development of a new vector platform for CXCR4-targeted molecular imaging and radionuclide therapy KU Leuven
The CXC chemokine receptor 4 (CXCR4) is a well-described G protein-coupled receptor (GCPR) that is involved in different physio-pathological processes upon binding of its endogenous ligand CXC chemokine 12 (CXCL12). CXCR4 is expressed throughout development and adulthood on a variety of cell types including lymphocytes, endothelial, epithelial and hematopoietic stem cells (HSCs). CXCR4 plays a fundamental physiological role in hematopoiesis, ...
The role of functional imaging and molecular profiling in image guided highly conformal radiotherapy for head and neck cancer: towards a patient tailored treatment. KU Leuven
Memory dependent PAth Sampling methods for understanding long TIMEscale molecular processes Ghent University
Time matters: timescales determine the fate, behavior and functionality of living matter. Especially the interplay between fast and slow molecular processes is omnipresent in biochemistry (protein folding, enzymatic conversions, molecular signaling, etc.). However, in chemistry, models are lacking to properly understand time and its effect on this difficult biological reality.
PASTIME will lay the methodological foundations for a ...