Projects
ADAM17 - A key regulator of microglia polarization after spinal cordinjury Hasselt University
DOT1L: a key regulator of growth factor signaling pathways in the joint KU Leuven
Osteoarthritis is the most common chronic joint disease with enormous societal costs. In osteoarthritis, structure and function of the joints are gradually affected leading to pain and disability. Current treatment options remain limited and no specific disease modifying drug strategies are available. We have contributed to the discovery that DOT1L, an enzyme that modulates gene expression in the cell nucleus, plays a role in this disease. In ...
The neuroblastoma-specific lncRNA NESPR as a key regulator of neuroblastoma cell identity and survival Ghent University
The neuroblastoma-specific lncRNA NESPR as a key regulator of neuroblastoma cell identity and survival
TRPM3 - a key regulator of inflammatory pain KU Leuven
About one in five adult Europeans suffer from moderate-to-severe chronic pain. In many cases, pain treatment with currently available analgesic drugs is insufficient to obtain sufficient pain relief. Moreover, stronger analgesic drugs, in particular opioids, are highly addictive and have the risk of fatal overdosing. Therefore, there is a high medical need for new analgesic drugs. Development of such drugs requires a deep understanding of the ...
Enlightening the Glycine Receptor α2 as a key regulator in the brain reward-pathway Hasselt University
Enlightening the Glycine Receptor α2 as a key regulator in the brain reward-pathway Hasselt University
ADAM17 - A key regulator of microglia polarization after spinal cord injury Hasselt University
Identification and characterization of novel key regulators of developmentally controlled programmed cell death in plants Ghent University
Programmed Cell Death (PCD) is fundamental to the development and health of multicellular organisms However, our knowledge on developmentally controlled PCD in plants remains fragmentary, despite its undoubted significance for plant growth and reproduction
My team has established the Arabidopsis root cap as a novel model system for developmental PCD in plants This model has enabled us to identify first transcription factors in a ...
3D genome topology and multi-omics in granulosa cells to decipher the regulation of FOXL2, a key factor in ovarian development and maintenance Ghent University
FOXL2 is a key transcription factor in ovarian development and maintenance throughout life. Despite advanced knowledge about its role, its transcriptional regulation in the ovary is poorly understood. Most of the insights into FOXL2 regulation come from non-coding genetic defects we found in blepharophimosis syndrome (BPES), a rare, autosomal dominant syndromic form of primary ovarian insufficiency (POI), and from a goat and mouse model. We ...