Projects
Role of intestinal angiogenesis on the occurrence of extraintestinal articular manifestations in inflammatory bowel disease Ghent University
Recent data show that enhanced angiognesis is present in the affected bowel of patients with inflammatory bowel disease (IBD). By immunologic investigations on human bowel tissue and by animal research we want to further elucidate the role of angiogenesis in IBD. We also want ot investigate whether intestinal angiogenesis could be involved in the occurrence of articular manifestations in patients with IBD.
Pharmacological strategies to inhibit intra-plaque angiogenesis in atherosclerosis. University of Antwerp
Air pollution as a CAtalyzer of defective angiogenesis Driving chronic thromboEmbolic pulMonary hypertension progression: Insights from in vivo and in vitro ApproachesAcronym: ACADEMIA KU Leuven
Finding new treatments for diseases where angiogenesis is insufficient such as ischemic stroke, wound healing and pulp regeneration. Hasselt University
INTERMITTENT EXOGENOUS KETOSIS DURING EXERCISE AND TRAINING: EXPLORING THE ROLEÂ OF DE NOVO ANGIOGENESIS AND EPIGENETIC REGULATION IN MUSCULAR ADAPTATION KU Leuven
The role of angiopoietin signaling on the regulation of angiogenesis by TIE2 expressing macrophages Ghent University
TIE2 expressing macrophages (TEMs) are important regulators of angiogenesis, i.e. the growth and remodeling of blood vessels. TEMs regulate initial blood vessel growth, but are also active during vascular remodeling and maturation. In this project we will investigate whether a balance between the TIE2 ligands, angiopoietin-1 and angiopoietin-2 drives TEMs to a pro-angiogenesis or a vessel maturation phenotype.
Role of angiogenesis and angiogenic growth factors (VEGF, PLGF) in portal hypertension and fibrosis formation in animal models of cirrhosis, steatosis and portal hypertension Ghent University
Models of portal hypertension and cirrhosis are used to study prevention and reversibility of collateral formation (in peripheral, splanchnic and pulmonary area), by treating mice with anti-PLGF and by using PLGF knock-out mice. Fibrosis formation and the role of hepatic stellate cells in the angiogenesis setting will be studied. In mice models of NASH will be the role of angiogenesis in fibrosis and colalteral formation studied in different ...
Regulation of placental development in horses: reciprocal parental control of angiogenesis in equine placenta and abnormal placental development. Ghent University
Pathological conditions of the placenta have significant effects on the health of fetus and mother. In mares, pathological conditions, such as fetal growth retardation, placentitis and hydrops, are associated with compromised placental vascularization. Using high-throughput data, we aim to gain insight into the regulatory mechanisms of vascularization in the normal and abnormal placenta and provide fundamental information on placental ...
Impact on angiogenesis and ER stress and its effect on chemoresistance through P1GF inhibition in a mice model of hepatocellular carcinoma. Ghent University
Hepatocellular carcinoma is third cause of cancer-related mortality. Cytostatics provide no improved survival. Chemoresistance modification is needed. Hypoxia and endoplasmic reticulum stress can cause chemoresistance. The efficacy of anti-P1GF suggests that this may be a future antineoplastic. Farnesylthiosalicylic acid is RAS competitor. HCC mouse model is used to evaluate anti-P1GF and farnesylthiosalicylic acid on hypoxia, ER stress and ...