Publications
Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo Hasselt University
Cognitive brain circuits and the spread of amyloid and tau in vivo in humans KU Leuven
Glycogen synthase kinase-3 beta, or a link between amyloid and tau pathology? KU Leuven
Differential role of CSF fatty acid binding protein 3, α-synuclein, and Alzheimer's disease core biomarkers in Lewy body disorders and Alzheimer's dementia Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Neurodegenerative disorders such as Alzheimer's disease (AD), Parkinson's disease with dementia (PDD), and dementia with Lewy bodies (DLB) share clinical and molecular features. Cerebrospinal fluid (CSF) biomarkers may help the characterization of these diseases, improving the differential diagnosis. We evaluated the diagnostic performance of five CSF biomarkers across a well-characterized cohort of patients diagnosed with AD, ...
Soluble amyloid precursor protein α and β in CSF in Alzheimer's disease Vrije Universiteit Brussel University of Antwerp
OBJECTIVE: Cerebral accumulation of amyloid β (Aβ) is a pathological hallmark of Alzheimer's disease (AD). Proteolytic processing of amyloid precursor protein (APP) by α- or β-secretase results in two soluble metabolites, sAPPα and sAPPβ, respectively. However, previous data have shown that both α- and β-secretase have multiple cleavage sites. The aim of this study was to characterize the C-termini of sAPPα and sAPPβ in cerebrospinal fluid ...
Diagnostic performance of cerebrospinal fluid neurofilament light chain and soluble amyloid-β protein precursor β in the subcortical small vessel type of dementia University of Antwerp
Cerebrospinal Fluid Fatty Acid-Binding Protein 3 is Related to Dementia Development in a Population-Based Sample of Older Adult Women Followed for 8 Years Vrije Universiteit Brussel University of Antwerp
BACKGROUND: Increased fatty acid-binding protein 3 (FABP-3) levels have been reported in neurodegenerative diseases, including Alzheimer's disease (AD). Cerebrospinal fluid (CSF) FABP-3 has therefore been proposed as a putative marker for dementia. Population-based studies examining whether CSF FABP-3 predicts later development of dementia are lacking.
OBJECTIVE: The aim of this study was to examine CSF levels of FABP-3 in relation to ...